Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 5/10/2022
Pimtrea Side Effects Center

What Is Pimtrea?

Pimtrea (desogestrel and ethinyl estradiol tablets, and ethinyl estradiol tablets) is an oral contraceptive indicated for the prevention of pregnancy in women who elect to use this product as a method of contraception. Pimtrea is available in generic form.

What Are Side Effects of Pimtrea?

Common side effects of Pimtrea include:

Dosage for Pimtrea

To achieve maximum contraceptive effectiveness, Pimtrea must be taken exactly as directed and at intervals not exceeding 24 hours. Tablets are taken without interruption as follows: One dark blue tablet daily for 21 days, one white (inert) tablet daily for 2 days followed by 1 green (ethinyl estradiol) tablet daily for 5 days. For all subsequent cycles, the patient then begins a new 28-tablet regimen on the next day after taking the last green tablet.

What Drugs, Substances, or Supplements Interact with Pimtrea?

Pimtrea may interact with:

Pimtrea During Pregnancy or Breastfeeding

Pimtrea is not recommended for use during pregnancy. Small amounts of Pimtrea pass into breast milk and may cause adverse reactions in nursing infants. Breastfeeding while using Pimtrea is not recommended.

Additional Information

Our Pimtrea (desogestrel and ethinyl estradiol tablets, and ethinyl estradiol tablets) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Which of the following are methods for contraception? See Answer
Pimtrea Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using birth control pills and call your doctor at once if you have:

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • liver problems--loss of appetite, upper stomach pain, tiredness, fever, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • increased blood pressure--severe headache, blurred vision, pounding in your neck or ears;
  • swelling in your hands, ankles, or feet;
  • changes in the pattern or severity of migraine headaches;
  • a breast lump; or
  • symptoms of depression--sleep problems, weakness, tired feeling, mood changes.

Common side effects may include:

  • nausea, vomiting (especially when you first start taking this medicine);
  • breast tenderness;
  • breakthrough bleeding;
  • acne, darkening of facial skin;
  • weight gain; or
  • problems with contact lenses.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Pimtrea (Desogestrel and Ethinyl Estradiol Tablets)


Choosing Your Birth Control Method See Slideshow
Pimtrea Professional Information


To report SUSPECTED ADVERSE REACTIONS, contact Northstar Rx LLC, Toll-Free at 1- 800-206-7821 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

An increased risk of the following serious adverse reactions has been associated with the use of oral contraceptives (see WARNINGS section):

There is evidence of an association between the following conditions and the use of oral contraceptives:

  • Mesenteric thrombosis
  • Retinal thrombosis

The following adverse reactions have been reported in patients receiving oral contraceptives and are believed to be drug-related:

  • Nausea
  • Change in weight (increase or decrease)
  • Vomiting
  • Change in cervical erosion and secretion
  • Gastrointestinal symptoms (such as abdominal cramps and bloating)
  • Diminution in lactation when given immediately postpartum
  • Breakthrough bleeding
  • Cholestatic jaundice
  • Spotting
  • Migraine
  • Change in menstrual flow
  • Rash (allergic)
  • Amenorrhea
  • Mental depression
  • Temporary infertility after discontinuation of treatment
  • Reduced tolerance to carbohydrates
  • Vaginal candidiasis
  • Edema
  • Change in corneal curvature (steepening)
  • Melasma which may persist
  • Intolerance to contact lenses
  • Breast changes: tenderness, enlargement, secretion

The following adverse reactions have been reported in users of oral contraceptives and the association has been neither confirmed nor refuted:

Read the entire FDA prescribing information for Pimtrea (Desogestrel and Ethinyl Estradiol Tablets)

© Pimtrea Patient Information is supplied by Cerner Multum, Inc. and Pimtrea Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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