Piqray vs. Ibrance

Are Piqray and Ibrance the Same Thing?

Piqray (alpelisib) and Ibrance (palbociclib) are kinase inhibitors used to treat breast cancer.

Piqray is indicated in combination with fulvestrant for the treatment of postmenopausal women, and men, with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer as detected by an FDA-approved test following progression on or after an endocrine-based regimen.

Ibrance is used in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease.

Side effects of Piqray and Ibrance that are similar include diarrhea, rash, nausea, fatigue, decreased appetite, inflammation of the mouth and lips, vomiting, hair loss, diarrhea, rash, nausea, fatigue, decreased appetite, inflammation of the mouth and lips, vomiting, hair loss, changes in taste, headache, and dry skin.

Side effects of Piqray that are different from Ibrance include weight loss, abdominal pain, indigestion, swelling of extremities, dry nose, urinary tract infection (UTI), itching, prolonged aPTT, and laboratory abnormalities (increased or decreased blood sugar, increased creatinine, decreased lymphocyte count, increased GGT, increased ALT, decreased hemoglobin, increased lipase, and decreased calcium).

Side effects of Ibrance that are different from Piqray include low white blood cell count (neutropenia), anemia (low red blood cell count), weakness, upper respiratory infection, mouth sores, low blood platelet count, numbness or tingling in the hands and feet, nosebleed, blurred vision, dry or watery eyes, and constipation.

Piqray may interact with CYP3A4 inducers, BCRP inhibitors, warfarin, and acid reducing agents.

Ibrance may also interact with azole antifungals, antiviral medications, clarithromycin, nefazodone, telithromycin, verapamil, grapefruit or grapefruit juice, phenytoin, rifampin, carbamazepine, St John's wort, bosentan, efavirenz, etravirine, modafinil, nafcillin, midazolam, alfentanil, cyclosporine, dihydroergotamine, ergotamine, everolimus, fentanyl, pimozide, quinidine, sirolimus, and tacrolimus.

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What Are Possible Side Effects of Piqray?

Side effects of Piqray include:

  • diarrhea
  • rash
  • nausea
  • fatigue
  • decreased appetite
  • inflammation of the mouth and lips
  • vomiting
  • weight loss
  • hair loss
  • abdominal pain
  • indigestion
  • swelling of extremities
  • fever
  • dry nose
  • urinary tract infection (UTI)
  • changes in taste
  • headache
  • itching
  • dry skin
  • prolonged aPTT
  • and laboratory abnormalities (increased or decreased blood sugar
  • increased creatinine
  • decreased lymphocyte count
  • increased GGT
  • increased ALT
  • decreased hemoglobin
  • increased lipase
  • and decreased calcium)

What Are Possible Side Effects of Ibrance?

Common side effects of Ibrance include:

  • neutropenia,
  • low white blood cell count,
  • anemia (low red blood cell count),
  • weakness,
  • fatigue,
  • anemia,
  • upper respiratory infection,
  • nausea,
  • inflammation of the mouth and lips,
  • mouth sores,
  • hair thinning or loss,
  • diarrhea,
  • low blood platelet count,
  • decreased appetite,
  • vomiting,
  • numbness or tingling in the hands and feet,
  • nosebleed,
  • blurred vision,
  • dry or watery eyes,
  • headache,
  • changes in taste,
  • constipation,
  • rash,
  • dry skin, or
  • fever.

What Is Piqray?

Piqray (alpelisib) is a kinase inhibitor indicated in combination with fulvestrant for the treatment of postmenopausal women, and men, with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer as detected by an FDA-approved test following progression on or after an endocrine-based regimen.

What Is Ibrance?

Ibrance (palbociclib) is a kinase inhibitor used in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease.

What Drugs Interact With Piqray?

Piqray may interact with CYP3A4 inducers, BCRP inhibitors, warfarin, and acid reducing agents. Tell your doctor all medications and supplements you use. Piqray is not recommended for use during pregnancy; it may harm a fetus. Piqray is used in combination with fulvestrant, which may also harm a fetus. It is unknown if Piqray passes into breast milk. Because of the potential for serious adverse reactions in the breastfed child, breastfeeding is not recommended during treatment with Piqray and for 1 week after the last dose.

What Drugs Interact With Ibrance?

Ibrance may interact with:

  • azole antifungals,
  • antiviral medications,
  • clarithromycin,
  • nefazodone,
  • telithromycin,
  • verapamil,
  • grapefruit or grapefruit juice,
  • phenytoin,
  • rifampin,
  • carbamazepine and St John's Wort,
  • bosentan,
  • efavirenz,
  • etravirine,
  • modafinil,
  • nafcillin,
  • midazolam,
  • alfentanil,
  • cyclosporine,
  • dihydroergotamine,
  • ergotamine,
  • everolimus,
  • fentanyl,
  • pimozide,
  • quinidine,
  • sirolimus, and
  • tacrolimus

Tell your doctor all medications and supplements you use.

How Should Piqray be Taken?

The recommended dose of Piqray is 300 mg (two 15 0 mg tablets) taken orally once daily with food.

How Should Ibrance be Taken?

The recommended dose of Ibrance is a 125 mg capsule taken orally once daily for 21 consecutive days followed by 7 days off treatment to comprise a complete cycle of 28 days. Ibrance should be taken with food in combination with letrozole 2.5 mg once daily given continuously throughout the 28-day cycle.

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References
Novartis. Piqray Product Information.

https://www.hcp.novartis.com/products/piqray/metastatic-breast-cancer/

Pfizer. Ibrance Product Information.
https://www.ibrance.com/

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