Last updated on RxList: 3/6/2018
Platinol Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 3/8/2019

Platinol (cisplatin) for Injection is a cancer medication used together with other medications to treat bladder cancer testicular cancer or ovarian cancer. The brand name Platinol is discontinued but generic versions may be available. Common side effects of Platinol include:

  • decreased sense of taste
  • nausea
  • vomiting
  • tired feeling
  • temporary hair loss
  • or pain
  • swelling
  • burning or
  • irritation around the IV needle.

The dose of Platinol depends on the type of cancer being treated. Platinol may interact with altretamine vitamin B6 seizure medications medicines to treat bowel disorders medications to prevent organ transplant rejection antiviral medications pain or arthritis medicines or injected antibiotics. Tell your doctor all medications and supplements you use. Do not use Platinol if you are pregnant. It could harm the fetus. Use birth control and tell your doctor if you become pregnant during treatment. This drug can pass into breast milk and may harm a nursing baby. Do not breastfeed while receiving this medication.

Our Platinol (cisplatin) for Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Platinol Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; fast heartbeats, feeling light-headed; wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat.

You may have a severe allergic reaction within minutes of receiving a cisplatin injection. Your caregivers will quickly treat you if you if this occurs.

Call your doctor at once if you have:

  • severe or ongoing nausea and vomiting;
  • vision problems, pain behind your eyes;
  • hearing problems, ringing in your ears;
  • pain, redness, swelling, or skin changes where the injection was given;
  • bone marrow suppression--dizziness, pale lips or fingernail beds, fast heart rate, getting easily tired or short of breath;
  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
  • low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough, trouble breathing; or
  • nervous system problems--decreased muscle reflexes, numbness and tingling or burning pain in your hands or feet.

Nervous system problems may occur up to several weeks after you receive cisplatin, and these effects may not be reversible. Talk to your doctor if you have concerns about this risk.

Nervous system problems may be more likely in older adults.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • hearing problems;
  • kidney problems;
  • numbness or tingling;
  • nausea, vomiting; or
  • bone marrow suppression.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Platinol (Cisplatin for Injection)


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Platinol Professional Information


The following adverse reactions are described in greater detail, in other sections:

Common adverse reactions are nephrotoxicity, peripheral neuropathy, nausea and vomiting myelosuppression, and ototoxicity. The following adverse reactions have been identified from clinical trials or post-marketing surveillance.

Blood and lymphatic system disorders: Coombs-positive hemolytic anemia. hemolytic uremic syndrome, thrombotic thrombocytopenic purpura

Cardiovascular disorders: Venous thromboembolism, arterial thromboembolism, myocardial infarction, cerebrovascular accident, thrombotic microangiopathy, cerebral arteritis, pericardial effusion, cardiac failure, ventricular dysfunction, Raynaud's phenomenon

Eye disorders: Optic neuritis, papilledema, cortical blindness, blurred vision, color blindness, retinal pigmentation

Gastrointestinal disorders: Nausea, vomiting, anorexia, diarrhea, stomatitis, gastrointestinal perforation, pancreatitis, hiccups

General disorders: Asthenia, malaise

Hepatobiliary disorders: Elevations of aminotransferases, lactate dehydrogenase, and bilirubin; hepatic failure

Hypersensitivity: Anaphylaxis, facial edema, wheezing, tachycardia, and hypotension

Local Site Reactions: Tissue cellulitis, fibrosis, necrosis, pain, edema, and erythema

Metabolism and nutrition disorders: Hypomagnesemia, often requiring magnesium supplementation; hyperuricemia, other electrolyte abnormalities (hypocalcemia, hyponatremia, hypokalemia, and hypophosphatemia), Syndrome of Inappropriate Antidiuretic Hormone Excretion (SIADH), dehydration, tumor lysis syndrome, increased serum amylase

Musculoskeletal disorders: Muscle cramps (localized, painful, involuntary skeletal muscle contractions of sudden onset and short duration)

Nervous system disorders: Peripheral neuropathy, Encephalopathy, loss of motor function, loss of taste, leukoencephalopathy, reversible posterior leukoencephalopathy syndrome, progressive multifocal leukoencephalopathy, seizures, Lhermitte's sign, dorsal column myelopathy, autonomic neuropathy, seizures, involuntary skeletal muscle contractions, tetany (with hypocalcemia and hypomagnesemia)

Ototoxicity: Tinnitus, hearing loss, deafness, vestibular toxicity

Renal and urinary disorders: Nephrotoxicity including renal failure, renal electrolyte wasting, azotemia, decreased creatinine clearance

Respiratory disorders: pneumonitis/interstitial lung disease, pulmonary embolism

Skin and subcutaneous tissue disorders: Alopecia, rash

Read the entire FDA prescribing information for Platinol (Cisplatin for Injection)

© Platinol Patient Information is supplied by Cerner Multum, Inc. and Platinol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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