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Plavix vs. Brilinta

Medical and Pharmacy Editor:

Are Brilinta and Plavix the Same Thing?

Plavix (clopidogrel bisulfate) and Brilinta (ticagrelor) are anticoagulants (blood thinners) that inhibit aspects of blood clotting and are used to treat patients with acute coronary syndrome, heart attack (myocardial infarction), peripheral vascular disease, and ischemic strokes.

What Are Possible Side Effects of Plavix?

Common side effects of Plavix include:

  • increased bleeding,
  • nosebleeds,
  • headaches,
  • itching, and
  • bruising.
Tell your doctor if you have serious side effects of Plavix including:
  • bleeding that will not stop;
  • bloody or tarry stools, blood in your urine;
  • coughing up blood or vomit that looks like coffee grounds;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden headache, confusion, problems with vision, speech, or balance;
  • pale skin, weakness, fever, or jaundice (yellowing of the skin or eyes);
  • unusual bleeding (nose, mouth, vagina, or rectum), or
  • purple or red pinpoint spots under your skin.

What Are Possible Side Effects of Brilinta?

Common side effects of Brilinta include:

  •  bruising
  • bleeding more easily
  • nosebleeds
  • headache
  • dizziness
  • cough
  • nausea
  • diarrhea
  • irregular heartbeat
  • high blood pressure
  • back pain
  • low blood pressure
  • fatigue, and
  • chest pain.

Tell your doctor if you experience serious side effects of Brilinta including severe bleeding or uncontrollable bleeding, shortness of breath, colored urine (pink, red, or brown), red or black stools (looks like tar), coughing or vomiting that produces blood or blood clots, or vomit that looks like coffee grounds.

What is Plavix?

Plavix (clopidogrel bisulfate) is a thienopyridine class of drug that inhibits platelet aggregation and thus inhibits aspects of blood clotting used to treat patients with acute coronary syndrome, myocardial infarction (MI), peripheral vascular disease and some stroke (ischemic type) patients. Plavix is available in generic form.

What is Brilinta?

Brilinta (ticagrelor) is a blood-thinner used to reduce cardiovascular death and heart attack in patients with acute coronary syndromes (ACS). Brilinta works by preventing the formation of new blood clots, thus maintaining blood flow in the body to help reduce the risk of another cardiovascular event.

What Drugs Interact With Plavix?

Plavix may interact with other blood thinners, antifungals, HIV/AIDS medications, or seizure medications.

Plavix may also interact with aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), armodafinil, modafinil, fluoxetine, fluvoxamine, gemfibrozil, isoniazid, cancer medications, or stomach acid reducers.

What Drugs Interact With Brilinta?

Brilinta may interact with other blood thinners, antifungals, HIV/AIDS medications, or seizure medications.

Brilinta may also interact with dexamethasone, digoxin, nefazodone, antibiotics, cholesterol-lowering medications, or heart or blood pressure medications.

How Should Plavix Be Taken?

Plavix is supplied as 75 and 300 mg tablets. For acute coronary syndrome with a non-ST elevation MI, the initial recommended dose is 300 mg, followed by a 75 mg dose per day; for ST elevation MIs, the initial and continuing dose is 75 mg per day. The recommended dose is 75 mg per day for patient with a history of MI, stroke, or peripheral vascular disease. Many doctors may choose to add an aspirin per day along with the Plavix dose in both non-ST elevation and ST elevation MIs as well as to stroke and peripheral vascular disease patients.

How Should Brilinta Be Taken?

Brilinta should be started with two 90 mg tablets as a loading dose, continuing treatment with 90 mg twice daily. After the initial loading dose of aspirin (usually 325 mg), use Brilinta with a daily maintenance dose of aspirin of 75-100 mg. Patients who have received a loading dose of clopidogrel may be started on Brilinta. A patient who misses a dose of Brilinta should take one 90 mg tablet (their next dose) at its scheduled time.

Reviewed on 5/11/2018

References:
Plavix Product Information.
http://www.plavix.com/
Brilinta Product Information.
https://www.brilinta.com/

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