Definition of Plexiform Neurofibroma

Reviewed on 10/18/2021

Plexiform neurofibroma is a tumor developing from the tissue that covers and protects nerves in the body outside the brain and spinal cord. Most plexiform neurofibromas are benign (not cancerous), but some may become cancerous. Plexiform neurofibromas are common in children with the rare genetic condition known as neurofibromatosis type 1. Plexiform neurofibromas can occur in various locations throughout the body, including the face, chest, abdomen, back, neck, extremities, or internal organs. Symptoms and signs depend on the location and size of the tumor and can include severe pain, vision loss, mobility problems, or hearing loss.


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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.

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