Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 6/14/2022
Podocon-25 Side Effects Center

What Is Podocon-25?

Podocon-25 (25% podophyllin in benzoin tincture) is a skin medication made from a powdered mixture of extracts from a plant called Mandrake, or May apple, used to treat genital warts on the outside of the penis or vagina, or on the skin between the rectum and the genitals. Podocon-25 may be available in generic form.

What Are Side Effects of Podocon-25?

Common side effects of Podocon-25 include:

  • mild bloating,
  • constipation,
  • application site reactions (slight stinging, pain, numbness, tingling, or burning),
  • fever, and
  • intestinal obstruction

Tell your doctor if you have serious side effects of Podocon-25 including:

  • severe burning,
  • stinging,
  • itching,
  • redness,
  • swelling, or
  • skin changes where the medicine was applied,
  • easy bruising or bleeding,
  • weakness, or
  • severe constipation or stomach cramps.

Dosage for Podocon-25

Podocon-25 resin is applied only by a physician, who will apply the proper dose to the affected area.

What Drugs, Substances, or Supplements Interact with Podocon-25?

It is not likely other drugs you take orally or inject will have an effect on topically applied Podocon-25 resin. But many drugs can interact with each other. Tell your doctor all prescription and over-the-counter medications and supplements you use.

Podocon-25 During Pregnancy or Breastfeeding

Podocon-25 is not recommended for use during pregnancy. It can cause birth defects. Do not use this drug if you are pregnant. Tell your doctor if you become pregnant during treatment. Use birth control while using this medication. It is unknown if this medication passes into breast milk or if it could harm a nursing baby. Do not use this medication if you are breastfeeding.

Additional Information

Our Podocon-25 (25% podophyllin in benzoin tincture) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Podocon-25 Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Topical medicine can be absorbed through the skin, which may cause side effects throughout the body. Call your doctor at once if you have:

  • change in your mental state, confusion, agitation, seizure (convulsions), loss of consciousness;
  • drowsiness or light-headed feeling (like you might pass out);
  • weak or shallow breathing;
  • severe constipation, little or no urinating;
  • weakness, numbness, tingling in your arms or legs;
  • easy bruising or bleeding (nosebleeds, bleeding gums), bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • upper stomach pain, loss of appetite; or
  • chest pain, pounding heartbeats or fluttering in your chest, shortness of breath.

Some side effects of podophyllum resin topical may not happen right away, and some may last for a week or longer.

Call your doctor at once if you have severe burning, stinging, or irritation after using this medication.

Common side effects may include:

  • swelling, redness, or tenderness of treated skin;
  • itching; or
  • burning pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Podocon-25 (Podophyllin)


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Podocon-25 Professional Information


The use of topical podophyllin has been known to result in paresthesia, polyneuritis, paralytic ileus, pyrexia, leukopenia, thrombocytopenia, coma and death(5).

Read the entire FDA prescribing information for Podocon-25 (Podophyllin)

© Podocon-25 Patient Information is supplied by Cerner Multum, Inc. and Podocon-25 Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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