Reviewed on 1/4/2023

What Is Podofilox and How Does It Work?

Podofilox is a prescription medication used for the treatment of Anogenital Warts. 

  • Podofilox is available under the following different brand names: Condylox

What Are Side Effects Associated with Using Podofilox?

Common side effects of Podofilox include:

  • Mild skin irritation (pain, swelling, burning, redness, itching, tingling, blisters, crusting, dryness, peeling) where the medicine was applied,
  • Headache,
  • Dizziness,
  • Sleep problems (insomnia),
  • Unpleasant skin odor,
  • Vomiting, and
  • Pain during sex

Serious side effects of Podofilox include:

  • Hives,
  • Difficulty breathing, and
  • Swelling of the face, lips, tongue, or throat, and
  • Severe itching, burning, oozing, bleeding, or skin changes where the medicine is applied

Rare side effects of Podofilox include:

  • none 

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

What Are the Dosages of Podofilox?

Adult dosage

Topical solution/gel

  • 0.5%

Anogenital Warts

Adult dosage

  • Apply with a cotton-tipped applicator (solution) or finger (gel) every 12 hours for 3 days then no treatment for 4 days
  • May repeat in 1 week, cycle up to 4 times

Dosage Considerations – Should be Given as Follows

  • See “Dosages”

What Other Drugs Interact with Podofilox?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Podofilox has no noted severe interactions with any other drugs.
  • Podofilox has no noted serious interactions with any other drugs.
  • Podofilox has no noted moderate interactions with any other drugs.
  • Podofilox has no noted minor interactions with any other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

What Are Warnings and Precautions for Podofilox?


  • Hypersensitivity

Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Podofilox?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Podofilox?”


  • Correct diagnosis of lesions to be treated essentially
  • Intended for cutaneous use only
  • Avoid contact with eyes; if contact with eyes occurs, patients should immediately flush their eyes with copious amounts of water and seek medical advice
  • Product is flammable; keep away from open flame
  • Data on the safe and effective use of this product for the treatment of warts occurring on mucous membranes of the genital area (including the urethra, rectum, and vagina), is not available
  • Do not exceed the frequency of application, duration of usage, and method of application

Pregnancy and Lactation

  • Use with caution if the benefits outweigh the risks during pregnancy.
  • Lactation
    • Not known whether topically applied podofilox is distributed into human milk, with the potential for serious adverse reactions in nursing infants

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