Polocaine Dental Side Effects Center

Last updated on RxList: 7/26/2022
Polocaine Dental Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

4>What Is Polocaine Dental?

Polocaine Dental (mepivacaine hydrochloride and levonordefrin injection) is a local anesthetic indicated for production of local anesthesia for dental procedures by infiltration or nerve block in adults and pediatric patients. The brand name Polocaine Dental has been discontinued; it may be available as a generic.

What Are Side Effects of Polocaine Dental?

Common side effects of Polocaine Dental include:

  • persistent numbness of the lips, tongue, and oral tissues

What are the possible side effects of Polocaine Dental?

Polocaine Dental may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • itching,
  • skin redness,
  • nausea,
  • vomiting,
  • sweating,
  • feeling hot,
  • fast heartbeats,
  • sneezing,
  • dizziness,
  • fainting,
  • numbness and tingling in your mouth or lips,
  • metallic taste in your mouth,
  • ringing in your ears,
  • blurred vision,
  • slurred speech,
  • headache,
  • confusion,
  • depression,
  • severe drowsiness,
  • lightheadedness,
  • slow heart rate,
  • weak pulse,
  • weak or shallow breathing,
  • fever,
  • neck stiffness,
  • increased sensitivity to light,
  • tremors or muscle twitching,
  • anxiety,
  • restlessness,
  • ongoing numbness,
  • weakness,
  • loss of movement in your legs or feet,
  • loss of bladder or bowel control,
  • loss of feeling in your lower stomach, groin, or genitals,
  • painful or difficult urination,
  • fast heart rate,
  • rapid breathing, and
  • feeling hot

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Polocaine Dental

The dose of Polocaine Dental varies and depends upon the area to be anesthetized, the vascularity of the tissues, individual tolerance and the technique of anesthesia. For infiltration and block injections in the upper or lower jaw, the average dose of 1 Polocaine Dental cartridge will usually suffice.

What Drugs, Substances, or Supplements Interact with Polocaine Dental?

Polocaine Dental may interact with local anesthetic solutions containing vasopressors, tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), vasopressor drugs, ergot-type oxytocic drugs, phenothiazines, butyrophenones, and vasoconstrictors. Tell your doctor all medications and supplements you use.

Polocaine Dental During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Polocaine Dental; it is unknown how it would affect a fetus. It is unknown if Polocaine Dental passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Polocaine Dental (mepivacaine hydrochloride and levonordefrin injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Polocaine Dental Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives, itching, skin redness; nausea, vomiting, sweating, feeling hot; fast heartbeats; sneezing, difficult breathing; dizziness, fainting; swelling of your face, lips, tongue, or throat.

Tell your caregiver right away if you have:

  • numbness and tingling in your mouth or lips, metallic taste in your mouth;
  • ringing in your ears, blurred vision, slurred speech, headache;
  • confusion, depression, severe drowsiness, feeling like you might pass out;
  • slow heart rate, weak pulse, weak or shallow breathing;
  • fever, neck stiffness, increased sensitivity to light;
  • tremors or muscle twitching, feeling anxious or restless;
  • ongoing numbness, weakness, or loss of movement in your legs or feet;
  • loss of bladder or bowel control;
  • loss of feeling in your lower stomach, groin, or genitals;
  • painful or difficult urination; or
  • fast heart rate, rapid breathing, feeling hot.

Common side effects may include:

  • anxiety, feeling restless or excited;
  • depression, dizziness;
  • tremors; or
  • blurred vision, ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Polocaine Dental (Mepivacaine Hydrochloride Injection)

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Polocaine Dental Professional Information

SIDE EFFECTS

Reactions to Polocaine® are characteristic of those associated with other amide-type local anesthetics. Systemic adverse reactions involving the central nervous system and the cardiovascular system usually result from high plasma levels (which may be due to excessive dosage, rapid absorption, inadvertent intravascular injection, or slow metabolic degradation), injection technique, or volume of injection.

A small number of reactions may result from hypersensitivity, idiosyncrasy or diminished tolerance to normal dosage on the part of the patient.

Persistent paresthesias of the lips, tongue, and oral tissues have been reported with the use of mepivacaine, with slow, incomplete, or no recovery. These post-marketing events have been reported chiefly following nerve blocks in the mandible and have involved the trigeminal nerve and its branches.

Reactions involving the central nervous system are characterized by excitation and/or depression. Nervousness, dizziness, blurred vision, or tremors may occur followed by drowsiness, convulsions, unconsciousness, and possible respiratory arrest. Since excitement may be transient or absent, the first manifestations may be drowsiness merging into unconsciousness and respiratory arrest.

Cardiovascular reactions are depressant. They may be the result of direct drug effect or more commonly in dental practice, the result of vasovagal reaction, particularly if the patient is in the sitting position. Failure to recognize premonitory signs such as sweating, feeling of faintness, changes in pulse or sensorium may result in progressive cerebral hypoxia and seizure or serious cardiovascular catastrophe. Management consists of placing the patient in the recumbent position and administration of oxygen. Vasoactive drugs such as Ephedrine or Methoxamine may be administered intravenously.

Allergic reactions are rare and may occur as a result of sensitivity to the local anesthetic and are characterized by cutaneous lesions of delayed onset or urticaria, edema and other manifestations of allergy. The detection of sensitivity by skin testing is of limited value. As with other local anesthetics, anaphylactoid reactions to mepivacaine have occurred rarely. The reaction may be abrupt and severe and is not usually dose related. Localized puffiness and swelling may occur.

Read the entire FDA prescribing information for Polocaine Dental (Mepivacaine Hydrochloride Injection)

© Polocaine Dental Patient Information is supplied by Cerner Multum, Inc. and Polocaine Dental Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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