Medical Editor: John P. Cunha, DO, FACOEP
What Is Poly-Pred?
Poly-Pred (prednisolone acetate, neomycin sulfate, polymyxin B sulfate ophthalmic suspension) is a combination of a steroid and antibiotics used to treat bacterial infections of the eyes. The brand name Poly-Pred is discontinued, but generic versions may be available.
What Are Side Effects of Poly-Pred?
Poly-Pred may cause serious side effects including:
- difficulty breathing,
- swelling of your face, lips, tongue, or throat, and
Get medical help right away, if you have any of the symptoms listed above.
Common side effects of Poly-Pred (prednisolone acetate, neomycin sulfate, polymyxin B sulfate ophthalmic suspension) include:
- stinging/burning of the eyes for 1 to 2 minutes when this medication is applied
- eye irritation
- blurred vision
- eyelid itching
- eyelid swelling, or
- sensitivity to light
Seek medical care or call 911 at once if you have the following serious side effects:
- Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
- Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
- Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
Dosage for Poly-Pred
The dose of Poly-Pred to treat the eye: Instill 1 or 2 drops every 3 or 4 hours, or more frequently as required. To treat the eyelids: Instill 1 or 2 drops in the eye every 3 to 4 hours, close the eye and rub the excess on the lids and lid margins.
What Drugs, Substances, or Supplements Interact with Poly-Pred?
Poly-Pred may interact with other eye medications, or oral steroids. Tell your doctor all medications and supplements you use.
Poly-Pred During Pregnancy or Breastfeeding
During pregnancy, Poly-Pred should be used only when prescribed. This drug passes into breast milk. Consult your doctor before breastfeeding.
Our Poly-Pred (prednisolone acetate, neomycin sulfate, polymyxin B sulfate ophthalmic suspension) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Adverse reactions have occurred with steroid/anti-infective combination drugs which can be attributed to the steroid component, the anti-infective component, or the combination. Exact incidence figures are not available since no denominator of treated patients is available.
Reactions occurring most often from the presence of the anti-infective ingredients are allergic sensitizations including itching, swelling, and conjunctival erythema (see WARNINGS). More serious hypersensitivity reactions, including anaphylaxis, have been reported rarely. The reactions due to the steroid component in decreasing order of frequency are: elevation of intraocular pressure (IOP) with possible development of glaucoma, and infrequent optic nerve damage; posterior subcapsular cataract formation; and delayed wound healing.
Although systemic effects are extremely uncommon, there have been rare occurences of systemic hypercorticoidism after use of topical steroids.
Corticosteroid-containing preparations have also been reported to cause perforation of the globe. Keratitis, conjunctivitis, corneal ulcers, and conjunctival hyperemia have occasionally been reported following local use of steroids.
Secondary infection: The development of secondary infection has occurred after use of combinations containing steroids and antimicrobials. Fungal infections of the cornea are particularly prone to develop coincidentally with long-term applications of steroids. The possibility of fungal invasion must be considered in any persistent corneal ulceration where steroid treatment has been used.
Secondary bacterial ocular infection following suppression of host responses also occurs.
Read the entire FDA prescribing information for Poly-Pred (Prednisolone,Neomycin and Polymyxin B)
© Poly-Pred Patient Information is supplied by Cerner Multum, Inc. and Poly-Pred Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.
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