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Polymyxin B

Last reviewed on RxList: 11/9/2017
Polymyxin B Side Effects Center

Last reviewed on RxList 11/09/2017

Polymyxin B (polymyxin b sulfate) is an antibiotic used to treat bacterial infections such as urinary tract infections, meningitis, blood infections, and eye infections. Polymyxin B is available in generic form. Common side effects of Polymyxin B include:

  • pain,
  • redness, and
  • swelling at the injection site, or
  • temporary eye stinging/burning/redness/itchiness or
  • temporary blurred vision if used as eye drops.

Contact your doctor if you experience serious side effects of Polymyxin B including:

  • flushing,
  • dizziness,
  • loss of coordination,
  • drowsiness,
  • fever,
  • headache,
  • numbness or tingling in the hands or feet,
  • back pain,
  • stiff neck,
  • unsteadiness,
  • hives, and
  • rash.

Polymyxin B dose is determined by a doctor, based on the condition being treated. It may be injected into a vein, muscle, or the spinal fluid or into the area around the eye (subconjunctival sac). It can also be prepared as eye drops. Polymyxin B may interact with other drugs that can harm the kidneys or nerves (e.g., cisplatin, colistin, high-dose aspirin, aminoglycosides such as amikacin, gentamicin, tobramycin, nonsteroidal anti-inflammatory drugs-NSAIDs such as ibuprofen or naproxen). Tell your doctor all medications you are taking. During pregnancy, Polymyxin B should be used only when prescribed. It is unknown if this medication passes into breast milk when used in the eye. It is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.

Our Polymyxin B (polymyxin b sulfate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Polymyxin B Professional Information

SIDE EFFECTS

See WARNING box.

Nephrotoxic reactions: Albuminuria, cylin-duria, azotemia, and rising blood levels without any increase in dosage.

Neurotoxic reactions: Facial flushing, dizziness progressing to ataxia, drowsiness, peripheral paresthesias (circumoral and stocking glove), apnea due to concurrent use of curariform muscle relaxants, other neurotoxic drugs or inadvertent overdosage, and signs of meningeal irritation with intrathecal administration, e.g., fever, headache, stiff neck and increased cell count and protein cerebrospinal fluid.

Other reactions occasionally reported: Drug fever, urticarial rash, pain (severe) at intramuscular injection sites, and thrombophlebitis at intravenous injection sites.

Read the entire FDA prescribing information for Polymyxin B (Polymyxin B Sulfate)

Related Resources for Polymyxin B

© Polymyxin B Patient Information is supplied by Cerner Multum, Inc. and Polymyxin B Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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