Slideshows Images Quizzes

Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.


Last reviewed on RxList: 8/6/2018
Polytrim Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 8/6/2018

Polytrim (polymyxin B sulfate and trimethoprim ophthalmic solution) is an antibiotic indicated in the treatment of surface bacterial infections of the eye, including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus viridans, Haemophilus influenzae and Pseudomonas aeruginosa. Polytrim is available in generic form. Common side effects of Polytrim include:

  • eye irritation (redness, burning, stinging, or itching), and
  • hypersensitivity reactions (eyelid swelling, itching, increased redness, tearing, or rash)

In mild to moderate infections, instill a dose of one drop of Polytrim in the affected eye(s) every three hours (maximum of 6 doses per day) for a period of 7 to 10 days. Polytrim may interact with other drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Polytrim; it is unknown how it would affect a fetus. It is unknown if Polytrim passes into breast milk. Consult your doctor before breastfeeding.

Our Polytrim (polymyxin B sulfate and trimethoprim ophthalmic solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Pink Eye (Conjunctivitis) Symptoms, Causes, Treatments See Slideshow
Polytrim Professional Information


The most frequent adverse reaction to POLYTRIM® Ophthalmic Solution is local irritation consisting of increased redness, burning, stinging, and/or itching. This may occur on instillation, within 48 hours, or at any time with extended use. There are also multiple reports of hypersensitivity reactions consisting of lid edema, itching, increased redness, tearing, and/or circumocular rash. Photosensitivity has been reported in patients taking oral trimethoprim.

Read the entire FDA prescribing information for Polytrim (Polymyxin B Sulfate and Trimethoprim Ophthalmic Solution, USP, Sterile)

Related Resources for Polytrim

Related Health

© Polytrim Patient Information is supplied by Cerner Multum, Inc. and Polytrim Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors