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Prednisone

Last reviewed on RxList: 7/14/2020
Prednisone Side Effects Center

What Is Prednisone?

Prednisone is a glucocorticoid indicated to treat or manage many conditions, including:

Prednisone tablets are available in generic form.

What Are Side Effects of Prednisone?

Common side effects prednisone include:

  • headache,
  • nausea,
  • vomiting,
  • acne, thinning skin,
  • weight gain,
  • restlessness, and
  • trouble sleeping.

Tell your doctor if you experience serious side effects of prednisone including

Dosage for Prednisone

The initial dosage of prednisone may vary from 5 mg to 60 mg per day, depending on the specific disease entity being treated.

What Drugs, Substances, or Supplements Interact with Prednisone?

Prednisone may interact with:

  • potassium-depleting agents (e.g., amphotericin B, diuretics),
  • macrolide antibiotics,
  • anticholinesterase,
  • anticoagulants,
  • antidiabetic drugs,
  • isoniazid,
  • bupropion,
  • cholestyramine,
  • cyclosporine,
  • digitalis glycosides,
  • estrogens (including oral contraceptives),
  • fluoroquinolones,
  • barbiturates,
  • phenytoin,
  • carbamazepine,
  • rifampin,
  • azole antifungals,
  • ritonavir,
  • indinavir,
  • nonsteroidal anti-inflammatory drugs (NSAIDs),
  • phenytoin,
  • quetiapine,
  • skin tests,
  • thalidomide, and
  • live or inactivated vaccines.

Tell your doctor all medications and supplements you use and all vaccines you recently received.

Prednisone and Pregnancy

During pregnancy, prednisone should be used only if prescribed. Infants born to mothers who have received substantial doses of steroids such as prednisone during pregnancy should be carefully observed for signs of hypoadrenalism. Prednisone passes into breast milk. Breastfeeding while using prednisone is not recommended.

Additional Information

Our Prednisone Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

About how much does an adult human brain weigh? See Answer
Prednisone Professional Information

SIDE EFFECTS

(listed alphabetically, under each subsection)

The following adverse reactions have been reported with prednisone or other corticosteroids:

Allergic Reactions

anaphylactoid or hypersensitivity reactions, anaphylaxis, angioedema.

Cardiovascular System

bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, ECG changes caused by potassium deficiency, edema, fat embolism, hypertension or aggravation of hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction (see WARNINGS: Cardio-Renal), necrotizing angiitis, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis.

Dermatologic

acne, acneiform eruptions, allergic dermatitis, alopecia, angioedema, angioneurotic edema, atrophy and thinning of skin, dry scaly skin, ecchymoses and petechiae (bruising), erythema, facial edema, hirsutism, impaired wound healing, increased sweating, Karposi's sarcoma (see PRECAUTIONS: General Precautions ), lupus erythematosus-like lesions, perineal irritation, purpura, rash, striae, subcutaneous fat atrophy, suppression of reactions to skin tests, striae, telangiectasis, thin fragile skin, thinning scalp hair, urticaria.

Endocrine

Adrenal insufficiency-greatest potential caused by high potency glucocorticoids with long duration of action (associated symptoms include; arthralgias, buffalo hump, dizziness, life-threatening hypotension, nausea, severe tiredness or weakness), amenorrhea, postmenopausal bleeding or other menstrual irregularities, decreased carbohydrate and glucose tolerance, development of cushingoid state, diabetes mellitus (new onset or manifestations of latent), glycosuria, hyperglycemia, hypertrichosis, hyperthyroidism (see WARNINGS: Endocrine), hypothyroidism, increased requirements for insulin or oral hypoglycemic agents in diabetics, lipids abnormal, moon face, negative nitrogen balance caused by protein catabolism, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery or illness) (see WARNINGS: Endocrine), suppression of growth in pediatric patients.

Fluid And Electrolyte Disturbances

congestive heart failure in susceptible patients, fluid retention, hypokalemia, hypokalemic alkalosis, metabolic alkalosis, hypotension or shock-like reaction, potassium loss, sodium retention with resulting edema.

Gastrointestinal

abdominal distention, abdominal pain,anorexia which may result in weight loss, constipation, diarrhea, elevation in serum liver enzyme levels (usually reversible upon discontinuation), gastric irritation, hepatomegaly, increased appetite and weight gain, nausea, oropharyngeal candidiasis, pancreatitis, peptic ulcer with possible perforation and hemorrhage, perforation of the small and large intestine (particularly in patients with inflammatory bowel disease), ulcerative esophagitis, vomiting.

Hematologic

anemia, neutropenia (including febrile neutropenia).

Metabolic

negative nitrogen balance due to protein catabolism.

Musculoskeletal

arthralgias, aseptic necrosis of femoral and humeral heads, increase risk of fracture, loss of muscle mass, muscle weakness, myalgias, osteopenia, osteoporosis (see PRECAUTIONS: Musculoskeletal), pathologic fracture of long bones, steroid myopathy, tendon rupture (particularly of the Achilles tendon), vertebral compression fractures.

Neurological/Psychiatric

amnesia, anxiety, benign intracranial hypertension, convulsions, delirium, dementia (characterized by deficits in memory retention, attention, concentration, mental speed and efficiency, and occupational performance), depression, dizziness, EEG abnormalities, emotional instability and irritability, euphoria, hallucinations, headache, impaired cognition, incidence of severe psychiatric symptoms, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, increased motor activity, insomnia, ischemic neuropathy, long-term memory loss, mania, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychiatric disorders including steroid psychoses or aggravation of pre-existing psychiatric conditions, restlessness, schizophrenia, verbal memory loss, vertigo, withdrawn behavior.

Ophthalmic

blurred vision, cataracts (including posterior subcapsular cataracts), central serous chorioretinopathy, establishment of secondary bacterial, fungal and viral infections, exophthalmos, glaucoma, increased intraocular pressure (see PRECAUTIONS: Ophthalmic), optic nerve damage, papilledema.

Other

abnormal fat deposits, aggravation/masking of infections, decreased resistance to infection (see WARNINGS: Infection), hiccups, immunosuppresion, increased or decreased motility and number of spermatozoa, malaise, insomnia, moon face, pyrexia.

To report SUSPECTED ADVERSE EVENTS, contact Actavis at 1-800-272-5525 or FDA at 1- 800-FDA-1088 or http://www.fda.gov/ for voluntary reporting of advers e reactions .

Read the entire FDA prescribing information for Prednisone (Prednisone Tablets, USP)

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow
Related Resources for Prednisone

© Prednisone Patient Information is supplied by Cerner Multum, Inc. and Prednisone Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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