Last updated on RxList: 5/5/2021

What is Prelone and how is it used?

Prelone is a prescription medicine used to treat the symptoms of Rheumatoid Arthritis and Multiple Sclerosis. Prelone may be used alone or with other medications.

Prelone belongs to a class of drugs called Corticosteroids.

What are the possible side effects of Prelone?

Prelone may cause serious side effects including:

  • cough,
  • sore throat,
  • fever,
  • chills,
  • white patches in your mouth,
  • vaginal discharge,
  • increased thirst,
  • increased urination,
  • unusual tiredness,
  • swelling of the ankles or feet,
  • unusual weight gain,
  • vision problems,
  • easy bruising or bleeding,
  • puffy face,
  • unusual hair growth,
  • mood changes,
  • depression,
  • mood swings,
  • agitation,
  • muscle weakness or pain,
  • thinning skin,
  • slow wound healing,
  • bone pain,
  • black or bloody stools,
  • vomit that looks like coffee grounds,
  • persistent stomach pain,
  • chest pain, and
  • seizures

Get medical help right away, if you have any of the symptoms listed above.

The most common side effects of Prelone include:

  • nausea,
  • heartburn,
  • headache,
  • dizziness,
  • menstrual period changes,
  • trouble sleeping,
  • increased sweating, and
  • acne

Tell the doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Prelone. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Prednisolone Syrup, USP contains prednisolone which is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.

Prednisolone is a white to practically white, odorless, crystalline powder. It is very slightly soluble in water; soluble in methanol and in dioxane; sparingly soluble in acetone and in alcohol; slightly soluble in chloroform.

The chemical name for Prednisolone is Pregna- 1,4- diene-3,20-dione, 11,17,21-trihydroxy-,(11ß)-. The structural formula is represented below:

Prednisolone syrup

PRELONE (prednisolone syrup) Syrup contains 15 mg of prednisolone in each 5 mL. Benzoic acid, 0.1% is added as a preservative. It also contains alcohol 5%, citric acid, edetate disodium, glycerin, propylene glycol, purified water, sodium saccharin, sucrose, artificial wild cherry flavor, FD&C blue #1 and red #40.