Premarin Injection

Last updated on RxList: 5/2/2012
Premarin Injection Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 3/28/2016

Premarin Intravenous (conjugated estrogens) for Injection is a form of a female hormone used to treat abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology. Premarin Intravenous is indicated for short-term use only, to provide a rapid and temporary increase in estrogen levels. Premarin Intravenous is available in generic form. Common side effects of Premarin Intravenous include:

For treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology the dose of Premarin Intravenous is one 25 mg injection, intravenously or intramuscularly. Premarin Intravenous may interact with blood thinners, rifampin, barbiturates, carbamazepine, griseofulvin, phenytoin, St. John's wort, primidone, erythromycin, ketoconazole, itraconazole, ritonavir, and grapefruit juice. Tell your doctor all medications and supplements you use. Premarin Intravenous should not be used during pregnancy. Premarin Intravenous may decease the quality and quantity of breast milk produced. Consult your doctor before breastfeeding.

Our Premarin Intravenous (conjugated estrogens) for Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Premarin Injection Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, sweating;
  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, coughing up blood, pain or warmth in one or both legs;
  • swelling, rapid weight gain;
  • jaundice (yellowing of the skin or eyes);
  • memory problems, confusion, unusual behavior;
  • unusual vaginal bleeding, pelvic pain;
  • a lump in your breast; or
  • high levels of calcium in your blood--vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.

Common side effects may include:

  • swelling;
  • hair loss;
  • numbness, tingling, burning pain;
  • back pain, leg cramps, pain;
  • bloating, gas, indigestion, nausea, vomiting, stomach pain;
  • dizziness, headache;
  • breast pain; or
  • vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Premarin Injection (Conjugated Estrogens for Injection)

Premarin Injection Professional Information



Premarin Intravenous for injection is indicated for short-term use. However, the warnings, precautions and adverse reactions associated with oral Premarin treatment should be taken into account.

The following adverse reactions have been identified during post-approval use of oral or intravenous Premarin. Because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Genitourinary system

Abnormal uterine bleeding/spotting.
Dysmenorrhea or pelvic pain.
Increase in size of uterine leiomyomata.
Vaginitis, including vaginal candidiasis.
Change in amount of cervical secretion.
Change in cervical ectropion.
Ovarian cancer.
Endometrial hyperplasia.
Endometrial cancer.


Tenderness, enlargement, pain, discharge, galactorrhea.
Fibrocystic breast changes.
Breast cancer.


Deep and superficial venous thrombosis.
Pulmonary embolism.
Myocardial infarction.
Increase in blood pressure.


Nausea, vomiting.
Abdominal cramps, bloating.
Cholestatic jaundice.
Increased incidence of gallbladder disease.
Enlargement of hepatic hemangiomas.
Ischemic colitis.


Chloasma or melasma that may persist when drug is discontinued.
Erythema multiforme.
Erythema nodosum.
Hemorrhagic eruption.
Loss of scalp hair.


Retinal vascular thrombosis.
Intolerance to contact lenses.

Central Nervous System

Mental depression.
Exacerbation of chorea.
Exacerbation of epilepsy.
Possible growth potentiation of benign meningioma.


Increase or decrease in weight.
Glucose intolerance.
Aggravation of porphyria.
Leg cramps.
Changes in libido.
Hypocalcemia (preexisting condition).
Injection site pain.
Injection site edema.
Phlebitis (injection site).
Exacerbation of asthma.
Increased triglycerides.

Read the entire FDA prescribing information for Premarin Injection (Conjugated Estrogens for Injection)

© Premarin Injection Patient Information is supplied by Cerner Multum, Inc. and Premarin Injection Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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