Prevalite

Last updated on RxList: 7/10/2019
Prevalite Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 7/10/2019

Prevalite (cholestyramine for oral suspension) powder is a cholesterol-lowering agent indicated as adjunctive therapy to diet for the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia (elevated low density lipoprotein [LDL] cholesterol) who do not respond adequately to diet. Prevalite powder may be useful to lower LDL cholesterol in patients who also have hypertriglyceridemia, but it is not indicated where hypertriglyceridemia is the abnormality of most concern. Common side effects of Prevalite include:

The recommended starting adult dose for Prevalite powder is one packet or one level scoopful (5.5 grams) once or twice a day. The recommended maintenance dose for Prevalite powder is 2 to 4 packets or scoopfuls daily (8 to 16 grams) divided into two doses. Prevalite may interact with phenylbutazone, warfarin, thiazide diuretics (acidic) or propranolol (basic), tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens, progestins, digitalis, oral phosphate supplements, and may prevent absorption of fat soluble vitamins such as A, D, E and K. Tell your doctor all medications and supplements you use. During pregnancy, Prevalite should be taken only if prescribed. Prevalite is known to interfere with absorption of fat-soluble vitamins and regular prenatal supplementation may not be adequate. Nursing mothers should use caution while taking Prevalite; the possible lack of proper vitamin absorption may affect a nursing infant. Consult your doctor before breastfeeding.

Our Prevalite (cholestyramine for oral suspension) powder Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Prevalite Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • ongoing or worsening constipation;
  • severe stomach pain;
  • blood in your urine;
  • black, bloody, or tarry stools; or
  • easy bruising, unusual bleeding.

Side effects such as constipation may be more likely in older adults.

Common side effects may include:

  • mild constipation, diarrhea;
  • stomach pain, nausea, loss of appetite;
  • bloating or gas;
  • irritation of your tongue; or
  • itching or irritation around your rectal area.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Prevalite (Cholestyramine for Oral Suspension, US)

SLIDESHOW

How to Lower Your Cholesterol & Save Your Heart See Slideshow
Prevalite Professional Information

SIDE EFFECTS

The most common adverse reaction is constipation. When used as a cholesterol-lowering agent, predisposing factors for most complaints of constipation are high dose and increased age (more than 60 years old). Most instances of constipation are mild, transient and controlled with conventional therapy. Some patients require a temporary decrease in dosage or discontinuation of therapy.

Less Frequent Adverse Reactions: Abdominal discomfort and/or pain, flatulence, nausea, vomiting, diarrhea, eructation, anorexia, steatorrhea, bleeding tendencies due to hypoprothrombinemia (Vitamin K deficiency) as well as Vitamin A (one case of night blindness reported) and D deficiencies, hyperchloremic acidosis in children, osteoporosis, rash and irritation of the skin, tongue and perianal area. Rare reports of intestinal obstruction, including two deaths, have been reported in pediatric patients.

Occasional calcified material has been observed in the biliary tree, including calcification of the gallbladder, in patients to whom cholestyramine resin has been given. However, this may be a manifestation of the liver disease and not drug related.

One patient experienced biliary colic on each of three occasions on which he took a cholestyramine for oral suspension product. One patient diagnosed as acute abdominal symptom complex was found to have a “pasty mass” in the transverse colon on x-ray.

Other events (not necessarily drug related) reported in patients taking cholestyramine resin include:

Gastrointestinal: GI-rectal bleeding, black stools, hemorrhoidal bleeding, bleeding from known duodenal ulcer, dysphagia, hiccups, ulcer attack, sour taste, pancreatitis, rectal pain, diverticulitis.

Laboratory Test Changes: Liver function abnormalities.

Hematologic: Prolonged prothrombin time, ecchymosis, anemia.

Hypersensitivity: Urticaria, asthma, wheezing, shortness of breath.

Musculoskeletal: Backache, muscle and joint pains, arthritis.

Neurologic: Headache, anxiety, vertigo, dizziness, fatigue, tinnitus, syncope, drowsiness, femoral nerve pain, paresthesia.

Eye: Uveitis.

Renal: Hematuria, dysuria, burnt odor to urine, diuresis.

Miscellaneous: Weight loss, weight gain, increased libido, swollen glands, edema, dental bleeding, dental caries, erosion of tooth enamel, tooth discoloration.

Read the entire FDA prescribing information for Prevalite (Cholestyramine for Oral Suspension, US)

© Prevalite Patient Information is supplied by Cerner Multum, Inc. and Prevalite Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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