Prinivil vs. Prinzide

Are Prinivil and Prinzide the Same Thing?

Prinivil (lisinopril) and Prinzide (lisinopril/hydrochlorothiazide) are used to treat high blood pressure (hypertension).

Prinivil is also used to treat heart failure and to improve survival after myocardial infarction (heart attack).

Both Prinivil and Prinzide contain an ACE (angiotensin converting enzyme) inhibitor. Prinzide also contains a thiazide diuretic (water pill).

What Are Possible Side Effects of Prinivil?

Common side effects of Prinivil include:

What Are Possible Side Effects of Prinzide?

Common side effects of Prinzide include:

Tell your doctor if you have unlikely but serious side effects of Prinzide including:

Tell your doctor if you have unlikely but serious side effects of Prinzide including:

  • fainting,
  • symptoms of a high potassium blood level (such as muscle weakness, slow or irregular heartbeat),
  • signs of infection (such as fever, chills, persistent sore throat),
  • unusual change in the amount of urine (not including the normal increase in urine when you first start this drug),
  • decrease in vision, or
  • eye pain.

What is Prinivil?

Prinivil (lisinopril) is a long-acting angiotensin converting enzyme (ACE) inhibitor used to treat hypertension, heart failure, and supportive treatment in patients that suffer a myocardial infarction (heart attack). Prinivil is available in generic form.

What is Prinzide?

Prinzide (lisinopril/hydrochlorothiazide) is a combination of an ACE (angiotensin converting enzyme) inhibitor and a thiazide diuretic (water pill) used to treat hypertension (high blood pressure).


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What Drugs Interact With Prinivil?

Prinivil may interact with other blood pressure medications.

Prinivil may also interact with gold injections, lithium, potassium supplements, salt substitutes that contain potassium, oral insulin or diabetes medications, aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs), or diuretics (water pills).

What Drugs Interact With Prinzide?

Prinzide may interact with other diuretics or blood pressure medications, gold injections to treat arthritis, lithium, cholestyramine or colestipol, steroids, NSAIDs (nonsteroidal anti-inflammatory drugs), insulin or oral diabetes medicines, cold or allergy medicine, sedatives, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety.

How Should Prinivil Be Taken?

Prinivil is available in doses of 5, 10, and 20 mg tablets for oral use. Hypertensive patients usually start with 10 mg once a day and are often increased to 20 mg. Patients with renal failure or are on diuretics start at lower doses such as 2.5 to 5 mg.

Heart attack and heart failure patients also start out with low doses of 5 mg one per day.

Prinivil is not recommended for use in children <6 years old or those that have a glomerular filtration rate <30 mL per min; pediatric doses are determined by weight.

How Should Prinzide Be Taken?

Each Prinzide tablet contains 10 mg of lisinopril and 12.5 mg of hydrochlorothiazide. Lisinopril is an effective treatment of hypertension in once-daily doses of 10-80 mg, while hydrochlorothiazide is effective in doses of 12.5-50 mg.


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DailyMed. Prinivil Product Information.

FDA. Prinzide Product Information.

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