Proamatine Side Effects Center

Last updated on RxList: 4/12/2021
Proamatine Side Effects Center

What Is Proamatine?

Proamatine (midodrine hydrochloride) is a vasopressor and antihypotensive drug used to treat low blood pressure. Proamatine is available in generic form.

What Are Side Effects of Proamatine?

Common side effects of Proamatine include:

  • skin tingling,
  • chills,
  • "goose bumps,"
  • stomach pain,
  • urinary problems (strong/frequent urge to urinate, frequent urination, trouble urinating),
  • itching skin,
  • feeling of pressure or fullness in the head,
  • nervousness, or
  • anxiety.

Less common side effects of Proamatine include:

  • dry mouth,
  • dizziness,
  • drowsiness,
  • trouble sleeping, or
  • leg cramps.

Tell your doctor immediately if you have unlikely but serious side effects of Proamatine including:

Dosage for Proamatine

The recommended dose of Proamatine is 10 mg, 3 times daily.

What Drugs, Substances, or Supplements Interact with Proamatine?

Proamatine may adversely interact with alpha adrenergic blockers, flecainide, cimetidine, ranitidine, digoxin, metformin, fludrocortisone, triamterene, quinidine, procainamide, and drugs that stimulate alpha-adrenergic receptors such as pseudoephedrine, phenylephrine, ephedrine, or dihydroergotamine.

Proamatine During Pregnancy and Breastfeeding

Proamatine is not recommended for use during pregnancy. It may harm a fetus. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Proamatine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Low Blood Pressure (Hypotension): Symptoms, Signs, Causes See Slideshow
Proamatine Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking midodrine and call your doctor at once if you have:

  • severely slowed heart rate--weak pulse, severe dizziness or light-headed feeling; or
  • dangerously high blood pressure--severe headache, pounding sensation in your ears ("hearing" your heartbeats), blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure.

Common side effects may include:

  • chills, goosebumps;
  • numbness, tingling, or itching (especially in your scalp);
  • headache, dizziness, tired feeling;
  • nausea; or
  • increased urination, painful or difficult urination, or sudden urge to urinate.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Proamatine (Midodrine Hydrochloride)

Proamatine Professional Information


The most frequent adverse reactions seen in controlled trials were supine and sitting hypertension; paresthesia and pruritus, mainly of the scalp; goosebumps; chills; urinary urge; urinary retention and urinary frequency.

The frequency of these events in a 3-week placebo-controlled trial is shown in the following table:

Adverse Events

Event Placebo
# of reports % of patients # of reports % of patients
Total # of reports 22 77
Paresthesia1 4 4.5 15 18.3
Piloerection 0 0 11 13.4
Dysuria2 0 0 11 13.4
Pruritis3 2 2.3 10 12.2
Supine hypertension4 0 0 6 7.3
Chills 0 0 4 4.9
Pain5 0 0 4 4.9
Rash 1 1.1 2 2.4
1 Includes hyperesthesia and scalp paresthesia
2 Includes dysuria (1), increased urinary frequency (2), impaired urination (1), urinary retention (5), urinary urgency (2)
3 Includes scalp pruritus
4 Includes patients who experienced an increase in supine hypertension
5 Includes abdominal pain and pain increase

Less frequent adverse reactions were headache; feeling of pressure/fullness in the head; vasodilation/flushing face; confusion/thinking abnormality; dry mouth; nervousness/anxiety and rash. Other adverse reactions that occurred rarely were visual field defect; dizziness; skin hyperesthesia; insomnia; somnolence; erythema multiforme; canker sore; dry skin; dysuria; impaired urination; asthenia; backache; pyrosis; nausea; gastrointestinal distress; flatulence and leg cramps.

The most potentially serious adverse reaction associated with ProAmatine® therapy is supine hypertension. The feelings of paresthesia, pruritus, piloerection and chills are pilomotor reactions associated with the action of midodrine on the alpha-adrenergic receptors of the hair follicles. Feelings of urinary urgency, retention and frequency are associated with the action of midodrine on the alpha-receptors of the bladder neck.

Read the entire FDA prescribing information for Proamatine (Midodrine Hydrochloride)

© Proamatine Patient Information is supplied by Cerner Multum, Inc. and Proamatine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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