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Probenecid and Colchicine

Last reviewed on RxList: 12/25/2016
Probenecid and Colchicine Side Effects Center

Last reviewed on RxList 1/31/2016

Probenecid and colchicine is a combination of a uricosuric agent and an antigout agent used to prevent gout attacks. Probenecid and colchicine will not cure gout and it will not stop a gout attack that has already started. Probenecid and colchicine is available in generic form. Common side effects of probenecid and colchicine include nausea, vomiting, stomach pain, cramping, diarrhea, loss of appetite, headache, dizziness, hair loss, flushing (warmth or tingly feeling), headache, and frequent urination.

The recommended adult dosage is 1 tablet of probenecid and colchicine daily for one week, followed by 1 tablet twice a day thereafter. Probenecid and colchicine may interact with amphotericin B, azathioprine, cyclophosphamide, flucytosine, ganciclovir, heparin, indomethacin, interferon, ketoprofen, mercaptopurine, methotrexate, nitrofurantoin, phenylbutazone, plicamycin, zidovudine, aspirin and other salicylates, medicines to treat tuberculosis or viral infections, or medicine to treat overactive thyroid. Tell your doctor all medications and supplements you use. During pregnancy, colchicine and probenecid should be used only if prescribed. It may be harmful to a fetus. It is unknown if this medication passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our probenecid and colchicine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Probenecid and Colchicine Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using colchicine and probenecid and call your doctor at once if you have any of these serious side effects:

  • painful urination, severe pain in your lower back or side;
  • easy bruising or bleeding, unusual weakness; or
  • severe diarrhea, nausea, vomiting, or stomach pain.

Continue using colchicine and probenecid and talk with your doctor if you have any of these less serious side effects:

  • mild nausea, vomiting, stomach pain, loss of appetite;
  • headache;
  • dizziness;
  • hair loss; or
  • warmth or tingly feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Probenecid and Colchicine (Probenecid and Colchicine)

Probenecid and Colchicine Professional Information


The following adverse reactions have been observed and within each category are listed in order of decreasing severity.


Central Nervous System: headache, dizziness.

Metabolic: precipitation of acute gouty arthritis.

Gastrointestinal:hepatic necrosis, vomiting, nausea, anorexia, sore gums.

Genitourinary: nephrotic syndrome, uric acid stones with or without hematuria, renal colic, costovertebral pain, urinary frequency.

Hypersensitivity: anaphylaxis, fever, urticaria, pruritus.

Hematologic: aplastic anemia, leukopenia, hemolytic anemia which in some patients could be related to genetic deficiency of glucose-6-phosphate dehydrogenase in red blood cells, anemia.

Integumentary: dermatitis, alopecia, flushing.


Side effects due to colchicines appear to be a function of dosage. The possibility of increased colchicine toxicity in the presence of hepatic dysfunction should be considered. The appearance of any of the following symptoms may require reduction of dosage or discontinuance of the drug.

Central Nervous System: peripheral neuritis.

Musculoskeletal: muscular weakness.

Gastrointestinal: nausea, vomiting, abdominal pain, or diarrhea may be particularly troublesome in the presence of peptic ulcer or spastic colon.

Hypersensitivity: urticaria.

Hematologic: aplastic anemia, agranulocytosis. Integumentary: dermatitis, purpura, alopecia.

At toxic doses, colchicine may cause severe diarrhea, generalized vascular damage, and renal damage with hematuria and oliguria.

Read the entire FDA prescribing information for Probenecid and Colchicine (Probenecid and Colchicine)

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© Probenecid and Colchicine Patient Information is supplied by Cerner Multum, Inc. and Probenecid and Colchicine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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