Procan Sr Side Effects Center

Last updated on RxList: 7/25/2022
Procan Sr Side Effects Center

What Is Procan SR?

Procan SR (procainamide) is an antiarrhythmic drug used to help keep the heart beating normally in people with certain heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). The brand name Procan SR is discontinued, but generic versions may be available.

What Are Side Effects of Procan SR?

Common side effects of Procan SR (procainamide) include:

Procan SR may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • new or worsening irregular heartbeat pattern,
  • chest pain,
  • wheezing,
  • lightheadedness,
  • chills,
  • sore throat,
  • flu symptoms,
  • pale skin,
  • easy bruising,
  • unusual bleeding (nosebleeds, bleeding gums),
  • loss of appetite,
  • nausea,
  • vomiting,
  • sores in your mouth and throat,
  • unusual weakness,
  • depression,
  • hallucinations,
  • severe dizziness,
  • upper stomach pain,
  • itching,
  • dark urine,
  • clay-colored stools,
  • yellowing of the skin or eyes (jaundice),
  • joint pain or swelling with fever,
  • swollen glands,
  • muscle pain,
  • weakness,
  • unusual thoughts or behavior,
  • patchy skin color, and
  • red spots on your skin

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Procan SR

An initial total daily oral dose of up to 50 mg/kg of body weight of Procan SR may be used, given in divided doses, every six hours, to maintain therapeutic blood levels.

What Drugs, Substances, or Supplements Interact with Procan SR?

Procan SR may interact with cimetidine, digoxin, glycopyrrolate, mepenzolate, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, bronchodilators, irritable bowel syndrome medications, bladder or urinary medications, or heart rhythm medications. Tell your doctor all medications and supplements you use.

Procan SR During Pregnancy or Breastfeeding

It is unknown if Procan SR will harm a fetus. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. This drug can pass into breast milk and may harm a nursing baby. Do not breastfeed while using Procan SR.

Additional Information

Our Procan SR (procainamide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Procan Sr Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your medical caregivers right away if you have:

  • sudden fever, chills, sore throat, mouth sores, weakness;
  • joint pain, muscle pain or weakness;
  • wheezing, chest pain;
  • easy bruising, pale or yellowed skin, dark colored urine;
  • depression, dizziness, hallucinations;
  • stomach pain, nausea, vomiting, diarrhea, loss of appetite; or
  • lupus-like symptoms--joint pain or swelling, stomach pain, chest pain, shortness of breath, and a rash or patchy skin color that worsens in sunlight.

Common side effects may include:

  • stomach pain, loss of appetite, nausea, vomiting, diarrhea;
  • dizziness, weakness, depressed mood;
  • abnormal liver function tests; or
  • rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Procan Sr Professional Information


Cardiovascular System: Hypotension following oral PA administration is rare. Hypotension and serious disturbances of cardiorhythm such as ventricular asystole or fibrillation are more common after intravenous administration (see OVERDOSAGE, WARNINGS). Second degree heart block has been reported in 2 of almost 500 patients taking PA orally.

Multisystem Effects: A lupus erythematosus-like syndrome of arthralgia, pleural or abdominal pain, and sometimes arthritis, pleural effusion, pericarditis, fever, chills, myalgia, and possibly related hematologic or skin lesions (see Below) is fairly common after prolonged PA administration, perhaps more often in patients who are slow acetylators (see


: Boxed Warning and PRECAUTIONS). While some series have reported less than 1 in 500, others have reported the syndrome in up to 30 percent of patients on long-term oral PA therapy. If discontinuation of PA does not reverse the lupoid symptoms, corticosteroid treatment may be effective.

Hematologic System: Neutropenia, thrombocytopenia, or hemolytic anemia may rarely be encountered. Agranulocytosis has occurred after repeated use of PA, and deaths have been reported. (see WARNINGS and


: Boxed Warning).

Skin: Angioneurotic edema, urticaria pruritus, flushing, and maculopapular rash have also occurred occasionally.

Gastrointestinal System: Anorexia, nausea, vomiting, abdominal pain, bitter taste, or diarrhea may occur in 3 to 4 percent of patients taking oral procainamide. Hepatomegaly with increased serum aminotransferase activity have been reported after a single oral dose.

Nervous System: Dizziness or giddiness, weakness, mental depression, and psychosis with hallucinations have been reported occasionally.

Read the entire FDA prescribing information for Procan Sr (Procainamide)

© Procan Sr Patient Information is supplied by Cerner Multum, Inc. and Procan Sr Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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