Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 4/27/2022
Proglycem Side Effects Center

What Is Proglycem?

Proglycem (oral diazoxide) is a non-diuretic benzothiadiazine derivative that works by preventing insulin release from the pancreas, helping to return the blood sugar to normal levels used to treat low blood sugar (hypoglycemia) related to certain cancers that affect the pancreas and cause it to release too much insulin.

What Are Side Effects of Proglycem?

Common side effects of Proglycem include nausea, vomiting, loss of appetite, stomach pain or upset, diarrhea, changes in sense of taste, temporary increase in growth of body hair (especially in women and children), headache, dizziness, anxiety, weakness, or itching or skin rash.

Dosage for Proglycem

The usual daily dosage of Proglycem for adults and children is 3 to 8 mg/kg, divided into two or three equal doses every 8 or 12 hours. The usual daily dosage for infants and newborns is 8 to 15 mg/kg divided into two or three equal doses every 8 to 12 hours.

What Drugs, Substances, or Supplements Interact with Proglycem?

Proglycem may interact with diuretics (water pills), chlorpromazine, phenytoin, blood thinners, or drugs to treat high blood pressure or a prostate disorder. Tell your doctor all medications and supplements you use.

Proglycem During Pregnancy and Breastfeeding

During pregnancy, Proglycem should be used only when prescribed. If you become pregnant, or think you may be pregnant, tell your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Proglycem (oral diazoxide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Proglycem Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • breathing problems in an infant or newborn treated with diazoxide;
  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • a light-headed feeling, like you might pass out; or
  • signs of high blood sugar (hyperglycemia) such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.

Common side effects may include:

  • pounding heartbeats or fluttering in your chest;
  • swelling in your hands, ankles, or feet;
  • fine hair growth on the face, arms, and back (especially in women or children);
  • nausea, vomiting, stomach pain, loss of appetite;
  • diarrhea, constipation; or
  • decreased sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Proglycem (Diazoxide Capsules)

Proglycem Professional Information


Frequent And Serious

Sodium and fluid retention is most common in young infants and in adults and may precipitate congestive heart failure in patients with compromised cardiac reserve. It usually responds to diuretic therapy (See DRUG INTERACTIONS).

Infrequent But Serious

Diabetic ketoacidosis and hyperosmolar nonketotic coma may develop very rapidly. Conventional therapy with insulin and restoration of fluid and electrolyte balance is usually effective if instituted promptly. Prolonged surveillance is essential in view of the long half-life of PROGLYCEM® (See OVERDOSE).

Other Frequent Adverse Reactions

Hirsutism of the lanugo type, mainly on the forehead, back and limbs, occurs most commonly in children and women and may be cosmetically unacceptable. It subsides on discontinuation of the drug.

Hyperglycemia or glycosuria may require reduction in dosage in order to avoid progression to ketoacidosis or hyperosmolar coma.

Gastrointestinal intolerance may include anorexia, nausea, vomiting, abdominal pain, ileus, diarrhea, transient loss of taste.

Tachycardia, palpitations, increased levels of serum uric acid are common.

Thrombocytopenia with or without purpura may require discontinuation of the drug. Neutropenia is transient, is not associated with increased susceptibility to infection, and ordinarily does not require discontinuation of the drug. Skin rash, headache, weakness, and malaise may also occur.

Other Adverse Reactions Which Have Been Observed Are

Cardiovascular: hypotension occurs occasionally, which may be augmented by thiazide diuretics given concurrently. A few cases of transient hypertension, for which no explanation is apparent, have been noted. Chest pain has been reported rarely. Pulmonary hypertension has been reported in neonates and young infants (see WARNINGS).

Hematologic: eosinophilia; decreased hemoglobin / hematocrit; excessive bleeding, decreased IgG.

Hepato-renal: increased AST, alkaline phosphatase; azotemia, decreased creatinine clearance, reversible nephrotic syndrome, decreased urinary output, hematuria, albuminuria. Neurologic: anxiety, dizziness, insomnia, polyneuritis, paresthesia, pruritus, extrapyramidal signs.

Ophthalmologic: transient cataracts, subconjunctival hemorrhage, ring scotoma, blurred vision, diplopia, lacrimation. Skeletal, integumentary; monilial dermatitis, herpes, advance in bone age; loss of scalp hair.

Systemic: fever, lymphadenopathy. Other; gout acute pancreatitis/pancreatic necrosis, galactorrhea, enlargement of lump in breast.

Read the entire FDA prescribing information for Proglycem (Diazoxide Capsules)

© Proglycem Patient Information is supplied by Cerner Multum, Inc. and Proglycem Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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