Prolia vs. Tymlos

• Are Prolia and Tymlos the Same Thing?
• What Are Possible Side Effects of Prolia?
• What Are Possible Side Effects of Tymlos?
• What is Prolia?
• What is Tymlos?
• What Drugs Interact with Prolia?
• What Drugs Interact with Tymlos?
• How Should Prolia Be Taken?
• How Should Tymlos Be Taken?

Prolia (denosumab) and Tymlos (abaloparatide) injection are used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause.

Prolia and Tymlos belong to different drug classes. Prolia is a monoclonal antibody and Tymlos injection is a human parathyroid hormone related peptide [PTHrP(1-34)] analog.

Common side effects of Prolia include:

• low calcium levels (especially if you have kidney problems),
• weakness,
• constipation,
• back pain,
• muscle pain,
• pain in your arms and legs,
• anemia,
• diarrhea, or
• skin problems (eczema, blisters, dry skin, peeling, redness, itching, small bumps).

You may also be more likely to get a serious infection, such as a skin, ear, stomach/gut, or bladder infection while taking Prolia. Tell your doctor if you develop signs of infection, such as:

• fever/chills, night sweats,
• red/swollen/tender/warm skin (with or without pus),
• severe stomach or abdominal pain,
• ear pain or drainage, trouble hearing,
• frequent/painful/burning urination, or
• pink/bloody urine.
• severe itching, burning, rask, blistering, peeling, or dryness of the skin,
• cough,
• shortness of breath,
• pinpoint purple or red spots under your skin,
• flu symptoms, or
• weight loss.

Common side effects of Tymlos include:

• high calcium levels in the urine (hypercalciuria),
• dizziness,
• nausea,
• headache,
• palpitations,
• fatigue,
• upper abdominal pain and
• spinning sensation (vertigo).

Prolia (denosumab) is a monoclonal antibody used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause.

Tymlos (abaloparatide) injection is a human parathyroid hormone related peptide [PTHrP(1-34)] analog indicated for the treatment of postmenopausal women with osteoporosis at high risk for fracture.

Prolia may interact with steroids or cancer medicine, cyclosporine, sirolimus, tacrolimus, basiliximab, muromonab-CD3, mycophenolate mofetil, azathioprine, leflunomide, or etanercept.

Tymlos may interact with other drugs. Tell your doctor all medications and supplements you use.

Prolia should be administered by a doctor. The recommended dose of Prolia is 60 mg administered as a single subcutaneous (under the skin) injection once every 6 months.

The recommended dose of Tymlos is 80 mcg subcutaneously once daily; patients should receive supplemental calcium and vitamin D if dietary intake is inadequate.