Brand Names: Promacta
Generic Name: eltrombopag
- What is eltrombopag (Promacta)?
- What are the possible side effects of eltrombopag (Promacta)?
- What is the most important information I should know about eltrombopag (Promacta)?
- What should I discuss with my health care provider before taking eltrombopag (Promacta)?
- How should I take eltrombopag (Promacta)?
- What happens if I miss a dose (Promacta)?
- What happens if I overdose (Promacta)?
- What should I avoid while taking eltrombopag (Promacta)?
- What other drugs will affect eltrombopag (Promacta)?
- Where can I get more information (Promacta)?
What is eltrombopag (Promacta)?
Eltrombopag is used to prevent bleeding episodes in adults and children age 1 year and older, who have chronic immune thrombocytopenic purpura (ITP). ITP is a bleeding condition caused by a lack of platelets in the blood.
Eltrombopag is not a cure for ITP and it will not make your platelet counts normal if you have this condition.
Eltrombopag is also used together with other medications to treat severe aplastic anemia in adults and children who are at least 2 years old.
Eltrombopag is sometimes given after other treatments have failed.
Eltrombopag may also be used for purposes not listed in this medication guide.
What are the possible side effects of eltrombopag (Promacta)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
- signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
- signs of a blood clot in the stomach--severe stomach pain, vomiting, diarrhea;
- signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
- signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs.
Call your doctor at once if you have:
- vision changes, tunnel vision, eye pain, or seeing halos around lights;
- flu symptoms such as fever, chills, cough, sore throat, headache, body aches, tired feeling;
- increased or frequent need to urinate, pain or burning when you urinate;
- low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
- liver problems--confusion, nausea, upper stomach pain, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
- nausea, vomiting, diarrhea, stomach pain, loss of appetite;
- cold symptoms such as stuffy nose, sneezing, cough, sore throat;
- fever, flu symptoms, anemia;
- mouth pain, tooth pain;
- muscle pain, back pain, headache;
- swelling in your feet or ankles;
- feeling weak or tired;
- sleep problems (insomnia);
- itching, tingling, or burning under your skin;
- skin rash;
- hair loss; or
- abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about eltrombopag (Promacta)?
Call your doctor at once if you have signs of liver problems: nausea, upper stomach pain, confusion, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
What should I discuss with my health care provider before taking eltrombopag (Promacta)?
You should not use eltrombopag if you are allergic to it.
Tell your doctor if you have ever had:
- a blood clot;
- liver disease (unless you are being treated for hepatitis C);
- kidney disease;
- myelodysplastic syndrome (also called "preleukemia");
- surgery to remove your spleen; or
- if you are of East Asian descent (Chinese, Japanese, Taiwanese, or Korean).
If you have myelodysplastic syndrome, taking eltrombopag can increase your risk of developing leukemia (a blood cancer that can be fatal). Talk with your doctor if you have concerns about this risk.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of eltrombopag on the baby.
You should not breast-feed while using this medicine.
How should I take eltrombopag (Promacta)?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Take eltrombopag on an empty stomach, at least 1 hour before or 2 hours after a meal.
Do not take eltrombopag with dairy products or calcium-fortified juice.
Mix the oral suspension powder only with water. Use a new dosing syringe each time you mix the medicine, to measure the water and to give the correct dose.
Swallow the tablet whole and do not crush, chew, or break it.
You will need frequent blood tests to check your liver function. Your eyes may also need to be checked for signs of cataract formation.
Eltrombopag doses are sometimes based on weight in children. Your child's dose needs may change if the child gains or loses weight.
If you take eltrombopag with medication to treat chronic hepatitis C, tell your doctor if you stop using any of your hepatitis medications.
Taking eltrombopag long-term can cause harmful effects on your bone marrow that may result in serious blood cell disorders.
It may take up to 4 weeks of taking eltrombopag before it is completely effective in preventing bleeding episodes. Keep taking the medicine as directed and tell your doctor if you have any bruising or bleeding episodes after 4 weeks of treatment.
Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative. After mixing eltrombopag oral suspension, store the liquid at room temperature and use it within 30 minutes.
After you stop taking eltrombopag, your risk of bleeding or bruising may be even higher than it was before you started treatment. Be extra careful to avoid cuts or injury for at least 4 weeks after you stop taking eltrombopag. Your blood will need to be tested weekly during this time.
What happens if I miss a dose (Promacta)?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose (Promacta)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking eltrombopag (Promacta)?
Avoid all dairy products or products that contain calcium (including fortified fruit juice) for at least 4 hours before or 2 hours after you take eltrombopag.
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
What other drugs will affect eltrombopag (Promacta)?
Some medicines can make eltrombopag much less effective when taken at the same time. If you take any of the following medicines, take your eltrombopag dose 2 hours before or 4 hours after you take the other medicine.
- an antacid; or
- vitamin or mineral supplements that contain aluminum, calcium, iron, magnesium, selenium, or zinc.
Tell your doctor about all your other medicines, especially:
- a blood thinner--warfarin, Coumadin, Jantoven; or
- cholesterol medication--atorvastatin, ezetimibe, fluvastatin, pitavastatin, pravastatin, rosuvastatin, or simvastatin.
This list is not complete. Other drugs may affect eltrombopag, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Where can I get more information (Promacta)?
Your doctor or pharmacist can provide more information about eltrombopag.
Copyright 1996-2019 Cerner Multum, Inc.