Medical Editor: John P. Cunha, DO, FACOEP
Promethazine HCl and Dextromethorphan Hydrobromide Syrup is a combination of an antihistamine and a cough suppressant used to treat cough, itching, runny nose, sneezing, and itchy or watery eyes caused by colds or allergies. Promethazine HCl and dextromethorphan hydrobromide syrup is available in generic form. Common side effects of Promethazine HCl and dextromethorphan hydrobromide syrup include:
- blurred vision
- dry mouth
- ringing in your ears
- increased sensitivity to sunlight
The dose of Promethazine HCl and Dextromethorphan Hydrobromide Syrup for adults is one tsp every 4 to 6 hours. Children 6 years to 12 years, the dose is one-half to one tsp every 4 to 6 hours. Children 2 years to 6 years, the dose is one-quarter to one-half tsp every 4 to 6 hours. Promethazine and Dextromethorphan may interact with elecoxib, cinacalcet, darifenacin, imatinib, quinidine, ranolazine, ritonavir, sibutramine, terbinafine, medicines to treat high blood pressure, antidepressants, sedatives or anxiety medicines, barbiturates, atropine, belladonna, clidinium, dicyclomine, glycopyrrolate, hyoscyamine, methscopolamine, and scopolamine. Tell your doctor all medications you use. During pregnancy, Promethazine HCl and Dextromethorphan Hydrobromide should be used only if prescribed. It is unknown if this medication passes into breast milk. It may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.
Our Promethazine HCl and Dextromethorphan Hydrobromide Syrup Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using dextromethorphan and promethazine and call your doctor at once if you have any of these serious side effects:
- uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
- tremors, twitching, or uncontrolled muscle movements in your face, arms, or legs.
- severe dizziness, anxiety, restless feeling, or nervousness;
- hallucinations (seeing or hearing things);
- confusion, hallucinations; or
- slow, shallow breathing, weak pulse;
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
- fever, muscle stiffness, confusion, fast or uneven heartbeat, sweating, fainting.
Keep taking dextromethorphan and promethazine and talk with your doctor if you have any of these less serious side effects:
- dizziness, drowsiness, sleepiness, or confusion;
- blurred vision, dry mouth;
- ringing in your ears;
- nausea or vomiting; or
- increased sensitivity to sunlight.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Promethazine HCl and Dextromethorphan Hydrobromide Syrup (Promethazine and Dextromethorphan)
Central Nervous System- Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported.
Hyperexcitability and abnormal movements have been reported in patients following a single administration of Promethazine HCl and Dextromethorphan Hydrobromide Syrup. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients.
Dextromethorphan hydrobromide occasionally causes slight drowsiness, dizziness, and gastrointestinal disturbances.
Drug Abuse And Dependence
According to the WHO Expert Committee on Drug Dependence, dextromethorphan could produce very slight psychic dependence but no physical dependence.
Read the entire FDA prescribing information for Promethazine HCl and Dextromethorphan Hydrobromide Syrup (Promethazine and Dextromethorphan)
© Promethazine HCl and Dextromethorphan Hydrobromide Syrup Patient Information is supplied by Cerner Multum, Inc. and Promethazine HCl and Dextromethorphan Hydrobromide Syrup Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.
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