Promethazine HCl Suppositories Side Effects Center

Last updated on RxList: 7/26/2022
Promethazine HCl Suppositories Side Effects Center

What Is Promethazine HCl Suppositories?

Promethazine hydrochloride suppositories (Brand Names: Phenadoz, Promethegan) is a phenothiazine that works by changing the actions of chemicals in your brain, and also acts as an antihistamine, used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. Promethazine hydrochloride suppositories is also used to prevent motion sickness, treat nausea and vomiting or pain after surgery, and as a sedative or sleep aid. Promethazine hydrochloride suppositories are available in generic form.

What Are Side Effects of Promethazine HCl Suppositories?

Common side effects of promethazine hydrochloride suppositories include:

Promethazine HCI Suppositories may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • severe drowsiness,
  • weak or shallow breathing,
  • lightheadedness,
  • confusion,
  • agitation,
  • hallucinations,
  • nightmares,
  • seizures,
  • fast, irregular, or slow heartbeats,
  • yellowing of the skin or eyes (jaundice),
  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement),
  • easy bruising,
  • unusual bleeding (nosebleeds, bleeding gums),
  • sudden weakness,
  • ill feeling,
  • fever,
  • chills,
  • sore throat,
  • mouth sores,
  • red or swollen gums,
  • trouble swallowing,
  • very stiff (rigid) muscles,
  • high fever,
  • sweating, and
  • tremors

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Promethazine HCl Suppositories

The dose of promethazine depends on the condition being treated. Typical doses range from 12.5 mg to 25 mg, and may be taken once daily or several times per day, as prescribed.

What Drugs, Substances, or Supplements Interact with Promethazine HCl Suppositories?

Promethazine may interact with:

Many other medicines can interact with promethazine. Tell your doctor all medications and supplements you use.

Promethazine HCl Suppositories During Pregnancy or Breastfeeding

During pregnancy, promethazine should be used only if prescribed. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Promethazine Hydrochloride Suppositories Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Promethazine HCl Suppositories Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe drowsiness, weak or shallow breathing;
  • a light-headed feeling, like you might pass out;
  • confusion, agitation, hallucinations, nightmares;
  • seizure (convulsions);
  • fast or slow heartbeats;
  • jaundice (yellowing of the skin or eyes);
  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
  • easy bruising or bleeding (nosebleeds, bleeding gums);
  • sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing; or
  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

  • drowsiness, dizziness;
  • ringing in your ears;
  • double vision;
  • feeling nervous;
  • dry mouth; or
  • tiredness, sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Promethazine HCl Suppositories (Promethazine Hydrochloride Suppositories)

Promethazine HCl Suppositories Professional Information

SIDE EFFECTS

Central Nervous System

Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported.

Cardiovascular - Increased or decreased blood pressure, tachycardia, bradycardia, faintness.

Dermatologic - Dermatitis, photosensitivity, urticaria.

Hematologic - Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis.

Gastrointestinal - Dry mouth, nausea, vomiting, jaundice.

Respiratory - Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal). (See WARNINGS-Respiratory Depression).

Other - Angioneurotic edema. Neuroleptic malignant syndrome (potentially fatal) has also been reported. (See WARNINGS-Neuroleptic Malignant Syndrome).

Paradoxical Reactions

Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients.

Read the entire FDA prescribing information for Promethazine HCl Suppositories (Promethazine Hydrochloride Suppositories)

© Promethazine HCl Suppositories Patient Information is supplied by Cerner Multum, Inc. and Promethazine HCl Suppositories Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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