Promethazine HCl Syrup

Last updated on RxList: 3/5/2021
Promethazine HCl Syrup Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Promethazine HCl Syrup?

Promethazine HCl Syrup is a phenothiazine used as a sedative, and to treat allergic reactions and nausea. Promethazine HCl Syrup is available in generic form.

What Are Side Effects of Promethazine HCl Syrup?

Common side effects of Promethazine HCl Syrup include:

Dosage for Promethazine HCl Syrup

The recommended dose of Promethazine HCl Syrup is 25 mg.

What Drugs, Substances, or Supplements Interact with Promethazine HCl Syrup?

Alcohol, narcotics, antidepressants, epinephrine, anticholinergics, and MAOIs may interact with Promethazine HCl Syrup. Tell your doctor all medications you take. Do not drive, use machinery, or do any activity that requires alertness when taking Promethazine HCl Syrup. Before taking Promethazine HCl Syrup tell your doctor if you have cardiovascular disease or impaired liver function.

Promethazine HCl Syrup During Pregnancy and Breastfeeding

If you are pregnant, only take Promethazine HCl Syrup if the potential benefit outweighs the potential risk to the fetus. Do not take Promethazine HCl Syrup if you are breastfeeding.

Additional Information

Our Promethazine HCl Syrup Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
Promethazine HCl Syrup Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using promethazine and call your doctor at once if you have:

  • severe drowsiness, weak or shallow breathing;
  • a light-headed feeling, like you might pass out;
  • confusion, agitation, hallucinations, nightmares;
  • seizure (convulsions);
  • fast or slow heartbeats;
  • jaundice (yellowing of the skin or eyes);
  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
  • easy bruising or bleeding (nosebleeds, bleeding gums);
  • sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing; or
  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Side effects such as confusion and severe drowsiness may be more likely in older adults.

Common side effects may include:

  • drowsiness, dizziness;
  • ringing in your ears;
  • double vision;
  • feeling nervous;
  • dry mouth; or
  • tired feeling, sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Promethazine HCl Syrup (Promethazine Hydrochloride Syrup Plain)

QUESTION

Allergies can best be described as: See Answer
Promethazine HCl Syrup Professional Information

SIDE EFFECTS

Central Nervous System- Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness, confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported.

Cardiovascular- Increased or decreased blood pressure, tachycardia, bradycardia, faintness.

Dermatologic - Dermatitis, photosensitivity, urticaria.

Hematologic - Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis.

Gastrointestinal- Dry mouth, nausea, vomiting, jaundice.

Respiratory - Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal). (See WARNINGS-Respiratory Depression.)

Other - Angioneurotic edema. Neuroleptic malignant syndrome (potentially fatal) has also been reported. (See WARNINGS-Neuroleptic Malignant Syndrome.)

Paradoxical Reactions

Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients.

Read the entire FDA prescribing information for Promethazine HCl Syrup (Promethazine Hydrochloride Syrup Plain)

© Promethazine HCl Syrup Patient Information is supplied by Cerner Multum, Inc. and Promethazine HCl Syrup Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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