Prometrium vs. Crinone

Are Crinone and Prometrium the Same Thing?

Prometrium (progesterone) and Crinone (progesterone) are forms of the female hormone progesterone used to treat secondary amenorrhea.

Prometrium is also prescribed to prevent endometrial hyperplasia in non-hysterectomized postmenopausal women receiving conjugated estrogens tablets.

Crinone is also used to treat infertile women with progesterone deficiency.

Prometrium and Crinone are taken in different forms. Prometrium is a capsule taken orally and Crinone is a bioadhesive vaginal gel.

What Are Possible Side Effects of Prometrium?

Common side effects of Prometrium include:

What Are Possible Side Effects of Crinone?

Common side effects of Crinone include:

Tell your doctor if you have serious side effects of Crinone including:

What Is Prometrium?

Prometrium (progesterone) is a progestin, a female hormone, prescribed for the prevention of endometrial hyperplasia in nonhysterectomized postmenopausal women receiving conjugated estrogens tablets and also for secondary amenorrhea. Prometrium is available as a generic drug.

What is Crinone?

Crinone (progesterone) gel is a bioadhesive vaginal gel contained in single-use, one-piece polyethylene vaginal applicators. Crinone is indicated as treatment for infertile women with progesterone deficiency and women with secondary amenorrhea. Crinone is available as a generic drug.

What Drugs Interact With Prometrium?

Drug interactions include inhibitors of cytochrome P450 3A4 (for example, ketoconazole), colchicine, dabigatran etexilate (Pradaxa), silodosin (Rapaflo) and aminoglutethimide (Cytadren). Do not use Prometrium without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Talk to your doctor about using birth control while you are using Prometrium.

What Drugs Interact With Crinone?

Crinone may interact with other drugs.

How Should Prometrium Be Taken?

Prometrium dose depends on the condition that is being treated.

How Should Crinone Be Taken?

Crinone is available in strengths of 4% gel (45 mg) and 8% gel (45 mg) in single use vaginal applicators. Crinone 4% is indicated for the treatment of secondary amenorrhea is dosed every other day for 6 total doses. Crinone 8% is indicated for use in women who have failed to respond to treatment with Crinone 4% but is dosed for infertility treatment at twice daily for 10 – 12 weeks.


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FDA. Prometrium Product Information.

Juniper Pharma. Crinone Product Information.

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