Prometrium vs. Provera

Are Provera and Prometrium the Same Thing?

Prometrium (progesterone) and Provera (medroxyprogesterone) are forms of the female hormone progesterone prescribed to prevent endometrial hyperplasia in non-hysterectomized postmenopausal women receiving conjugated estrogens tablets and also for secondary amenorrhea.

Provera is also used to treat abnormal bleeding from the uterus due to hormonal imbalance and not due to fibroids, or cancer; for contraception; and for treating endometrial or renal cancer.

What Are Possible Side Effects of Prometrium?

Common side effects of Prometrium include:

What Are Possible Side Effects of Provera?

Common side effects of Provera include:

  • breast tenderness or discharge,
  • hives,
  • itching,
  • skin rash,
  • increased acne,
  • hair growth,
  • loss of scalp hair,
  • spotting or break-through bleeding,
  • changes in menstrual periods,
  • vaginal itching or discharge,
  • changes in appetite,
  • increased or decreased weight,
  • nausea,
  • stomach pain,
  • bloating,
  • fever,
  • sleep problems (insomnia), and
  • jaundice (yellowing of the skin or eyes), or
  • skin color changes.

Provera may increase risk of heart attacks, stroke, breast cancer, blood clots, and pulmonary emboli in postmenopausal women.

What Is Prometrium?

Prometrium (progesterone) is a progestin, a female hormone, prescribed for the prevention of endometrial hyperplasia in nonhysterectomized postmenopausal women receiving conjugated estrogens tablets and also for secondary amenorrhea. Prometrium is available as a generic drug.

What is Provera?

Provera (medroxyprogesterone) is a form of the female hormone progesterone used to treat secondary amenorrhea; abnormal bleeding from the uterus due to hormonal imbalance and not due to fibroids, or cancer; and to prevent endometrial hyperplasia in postmenopausal women who have not undergone a hysterectomy and are receiving conjugated estrogens. Provera is used for contraception and for treating endometrial or renal cancer.

What Drugs Interact With Prometrium?

Drug interactions include inhibitors of cytochrome P450 3A4 (for example, ketoconazole), colchicine, dabigatran etexilate (Pradaxa), silodosin (Rapaflo) and aminoglutethimide (Cytadren). Do not use Prometrium without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Talk to your doctor about using birth control while you are using Prometrium.

What Drugs Interact With Provera?

Provera may interact with other drugs. Tell your doctor all medications and supplements you use. Avoid smoking while taking Provera due to a greatly increased risk of blood clots. Provera passes into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

How Should Prometrium Be Taken?

Prometrium dose depends on the condition that is being treated.

How Should Provera Be Taken?

The dose of Provera varies depending on the indication. Provera inhibits fertility at high doses.


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FDA. Prometrium Product Information.

Pfizer. Provera Product Information.

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