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Last reviewed on RxList: 11/18/2016
Propine Side Effects Center

Last reviewed on RxList 4/28/2016

Propine (dipivefrin HCI ophthalmic solution) works by regulating the flow of fluid within the eye to maintain a normal pressure and is used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). Propine is available in generic form. Common side effects of Propine include:

  • burning/stinging/irritation/itching of the eyes
  • redness of the eye or eyelid
  • eye pain
  • blurred vision
  • headache, and
  • increased sensitivity to light

The usual dosage of Propine is one drop in the eye(s) every 12 hours. Other drugs may interact with Propine ophthalmic. Avoid using any eye medications your doctor has not prescribed. Tell your doctor all medications and supplements you use. Propine should be used only when prescribed during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Propine (dipivefrin HCI ophthalmic solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Propine Consumer Information

Stop using dipivefrin and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe stinging or burning in your eyes;
  • fast or uneven heart rate; or
  • high blood pressure (severe headache, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath).

Less serious side effects may include:

  • burning, stinging, or itching of your eyes;
  • blurred vision;
  • redness of the eye or eyelid;
  • sensitivity to light;
  • eye pain; or
  • headache.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Propine (Dipivefrin)

Propine Professional Information


Cardiovascular Effects

Tachycardia, arrhythmias and hypertension have been reported with ocular administration of epinephrine.

Local Effects

The most frequent side effects reported with PROPINE® (dipivefrin) alone were injection in 6.5% of patients and burning and stinging in 6%. Follicular conjunctivitis, eye pain, mydriasis, blurry vision, eye pruritus, headache and allergic reaction to PROPINE® (dipivefrin) ophthalmic solution have been reported. Epinephrine therapy can lead to adrenochrome deposits in the conjunctiva and cornea.

Read the entire FDA prescribing information for Propine (Dipivefrin)

Related Resources for Propine

© Propine Patient Information is supplied by Cerner Multum, Inc. and Propine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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