Last updated on RxList: 11/18/2016
Propine Side Effects Center

Last reviewed on RxList 4/28/2016

Propine (dipivefrin HCI ophthalmic solution) works by regulating the flow of fluid within the eye to maintain a normal pressure and is used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). Propine is available in generic form. Common side effects of Propine include:

  • burning/stinging/irritation/itching of the eyes
  • redness of the eye or eyelid
  • eye pain
  • blurred vision
  • headache, and
  • increased sensitivity to light

The usual dosage of Propine is one drop in the eye(s) every 12 hours. Other drugs may interact with Propine ophthalmic. Avoid using any eye medications your doctor has not prescribed. Tell your doctor all medications and supplements you use. Propine should be used only when prescribed during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Propine (dipivefrin HCI ophthalmic solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Propine Consumer Information
SIDE EFFECTS: Burning/stinging/irritation/redness of the eye, blurred vision, headache, and increased sensitivity to light may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Although unlikely, this medication may cause dark staining on your eyes. Tell your doctor promptly if this occurs.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: eye pain/swelling, severe headaches, fast/irregular heartbeat.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Propine (Dipivefrin)


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Propine Professional Information


Cardiovascular Effects

Tachycardia, arrhythmias and hypertension have been reported with ocular administration of epinephrine.

Local Effects

The most frequent side effects reported with PROPINE® (dipivefrin) alone were injection in 6.5% of patients and burning and stinging in 6%. Follicular conjunctivitis, eye pain, mydriasis, blurry vision, eye pruritus, headache and allergic reaction to PROPINE® (dipivefrin) ophthalmic solution have been reported. Epinephrine therapy can lead to adrenochrome deposits in the conjunctiva and cornea.

Read the entire FDA prescribing information for Propine (Dipivefrin)

© Propine Patient Information is supplied by Cerner Multum, Inc. and Propine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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