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Propylthiouracil

Last reviewed on RxList: 10/2/2020
Propylthiouracil Side Effects Center

What Is Propylthiouracil?

Propylthiouracil is an antithyroid drug used to treat hyperthyroidism (overactive thyroid) or Graves' disease. Propylthiouracil is available in generic form.

What Are Side Effects of Propylthiouracil?

Common side effects of propylthiouracil include:

  • stomach upset,
  • nausea,
  • vomiting,
  • mild rash or itching,
  • headache,
  • dizziness,
  • spinning sensation,
  • joint or muscle pain,
  • decreased sense of taste, or
  • hair loss.

Tell your doctor immediately if you have rare but serious side effects of propylthiouracil including:

Propylthiouracil may rarely cause very serious blood disorders (such as a low number of red cells, white cells, and platelets), especially during the first few months of treatment. Tell your doctor if you develop any of the following symptoms:

  • signs of infection (such as fever, persistent sore throat),
  • easy bruising or bleeding, or
  • unusual tiredness.

Dosage for Propylthiouracil?

The initial adult dose of propylthiouracil is 300 mg daily. The usual maintenance dosage is 100 to 150 mg daily. For children 6 to 10 years of age, the initial dosage is 50 to 150 mg daily. For pediatric patients 10 years and over, the initial dosage is 150 to 300 mg daily.

What Drugs, Substances, or Supplements Interact with Propylthiouracil?

Propylthiouracil may interact with digoxin, theophylline, blood thinners, or beta-blockers. Tell your doctor all medications and supplements you use.

Propylthiouracil During Pregnancy and Breastfeeding

Propylthiouracil should be used only when prescribed during the first 3 months of pregnancy. It is not recommended for use during the last 6 months of pregnancy. If you are planning pregnancy, become pregnant, or think you may be pregnant, contact your doctor. This medication passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Propylthiouracil Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Where is the thyroid gland located? See Answer
Propylthiouracil Consumer Information

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Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Propylthiouracil can cause liver damage (especially during the first 6 months of treatment). Liver failure can be fatal or may require a liver transplant. Stop taking propylthiouracil and call your doctor right away if you have signs of liver damage:

  • nausea, vomiting, upper stomach pain;
  • itching;
  • fever, tiredness;
  • loss of appetite;
  • dark urine, clay-colored stools; or
  • jaundice (yellowing of the skin or eyes).

Also call your doctor at once if you have:

  • fever, chills, sore throat, mouth sores, feeling light-headed;
  • unusual bleeding;
  • purple or red discoloration of your skin;
  • skin rash, skin pain or swelling;
  • pink or dark urine, foamy urine, little or no urination;
  • shortness of breath, or if you cough up blood; or
  • new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.

Common side effects may include:

  • nausea, vomiting, stomach pain;
  • itching or tingling;
  • joint or muscle pain;
  • swollen glands;
  • headache, drowsiness, dizziness;
  • swelling in your hands or feet;
  • decreased sense of taste; or
  • hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Propylthiouracil (Propylthiouracil Tablet)

SLIDESHOW

Hyperthyroidism Symptoms and Treatment See Slideshow
Propylthiouracil Professional Information

SIDE EFFECTS

The following adverse reactions have been reported with the use of propylthiouracil. Because these events generally come from voluntary reporting from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Severe adverse reactions include liver injury presenting as hepatitis, liver failure necessitating liver transplantation or resulting in death (see WARNINGS). Inhibition of myelopoiesis (agranulocytosis, granulopenia, aplastic anemia, and thrombocytopenia), drug fever, a lupus-like syndrome (including splenomegaly and vasculitis), periarteritis, hypoprothrombinemia, and bleeding have been reported. Nephritis, glomerulonephritis, interstitial pneumonitis, exfoliative dermatitis, and erythema nodosum have also been reported.

There are reports of a vasculitis associated with the presence of anti-neutrophilic cytoplasmic antibodies (ANCA), resulting in severe complications and death (see WARNINGS).

There have been rare reports of serious hypersensitivity reactions (e.g., Stevens Johnson syndrome and toxic epidermal necrolysis) in patients treated with propylthiouracil. Other adverse reactions include skin rash, uticaria, nausea, vomiting, epigastric distress, arthralgia, paresthesias, loss of taste, taste perversion, abnormal loss of hair, myalgia, headache, pruritus, drowsiness, neuritis, edema, vertigo, skin pigmentation, jaundice, sialadenopathy, and lymphadenopathy.

To report SUSPECTED ADVERSE EVENTS, contact Actavis at 1-800-432-8534 or FDA at 1-800-FDA- 1088 or http://www.fda.gov/ for voluntary reporting of adverse reactions.

Read the entire FDA prescribing information for Propylthiouracil (Propylthiouracil Tablet)

Related Resources for Propylthiouracil

Related Health

Read the Propylthiouracil User Reviews »

© Propylthiouracil Patient Information is supplied by Cerner Multum, Inc. and Propylthiouracil Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

QUESTION

Where is the thyroid gland located? See Answer

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