Prostigmin

Last updated on RxList: 4/27/2021
Prostigmin Side Effects Center

What Is Prostigmin?

Prostigmin (neostigmine) is an anticholinesterase agent used to treat the symptoms of myasthenia gravis. Prostigmin may be available in generic form.

What Are Side Effects of Prostigmin?

Common side effects of Prostigmin include:

  • nausea,
  • vomiting,
  • diarrhea,
  • abdominal cramps,
  • increased saliva/mucus,
  • decreased pupil size,
  • increased urination,
  • increased sweating or cold sweat,
  • headache,
  • drowsiness,
  • gas,
  • warmth or tingly feeling, or
  • rash or itching.

Tell your doctor if you have unlikely but serious side effects of Prostigmin including:

  • new or increased muscle cramps/weakness/twitching,
  • new or increased difficulty swallowing,
  • slow/fast/irregular heartbeat,
  • dizziness,
  • shortness of breath,
  • headache, or
  • seizures.

Dosage for Prostigmin

Dosage requirements of Prostigmin for optimal results vary from 15 mg to 375 mg per day.

What Drugs, Substances, or Supplements Interact with Prostigmin?

Prostigmin may interact with atropine, belladonna, clidinium, dicyclomine, glycopyrrolate, hyoscyamine, mepenzolate, methantheline, methscopolamine, propantheline, scopolamine, antibiotics, or heart rhythm medications. Tell your doctor all medications you use.

Prostigmin During Pregnancy or Breastfeeding

During pregnancy, Prostigmin should be used only when prescribed. It is unknown if this drug passes into breast milk. Similar drugs pass into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Prostigmin (neostigmine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow
Prostigmin Consumer Information
SIDE EFFECTS: Nausea, vomiting, diarrhea, abdominal cramps, increased saliva/mucus, decreased pupil size, increased urination, or increased sweating may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: new or increased muscle cramps/weakness/twitching, new or increased difficulty swallowing, slow/fast/irregular heartbeat, dizziness, shortness of breath, headache, seizures.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Prostigmin (Neostigmine)

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Prostigmin Professional Information

SIDE EFFECTS

Side effects are generally due to an exaggeration of pharmacological effects of which salivation and fasciculation are the most common. Bowel cramps and diarrhea may also occur.

The following additional adverse reactions have been reported following the use of either neostigmine bromide or neostigmine methylsulfate:

Allergic: Allergic reactions and anaphylaxis.

Neurologic: Dizziness, convulsions, loss of consciousness, drowsiness, headache, dysarthria, miosis and visual changes.

Cardiovascular: Cardiac arrhythmias (including bradycardia, tachycardia, A-V block and nodal rhythm) and nonspecific EKG changes have been reported, as well as cardiac arrest, syncope and hypotension. These have been predominantly noted following the use of the injectable form of Prostigmin (neostigmine) .

Respiratory: Increased oral, pharyngeal and brochial secretions, and dyspnea. Respiratory depression, respiratory arrest and bronchospasm have been reported following the use of the injectable form of Prostigmin (neostigmine) .

Dermatologic: Rash and urticaria.

Gastrointestinal: Nausea, emesis, flatulence and increased peristalsis.

Genitourinary: Urinary frequency.

Musculoskeletal: Muscle cramps and spasms, arthralgia.

Miscellaneous: Diaphoresis, flushing and weakness.

Read the entire FDA prescribing information for Prostigmin (Neostigmine)

© Prostigmin Patient Information is supplied by Cerner Multum, Inc. and Prostigmin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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