Medical Editor: John P. Cunha, DO, FACOEP
- abdominal cramps,
- increased saliva/mucus,
- decreased pupil size,
- increased urination,
- increased sweating or cold sweat,
- warmth or tingly feeling, or
- rash or itching.
Tell your doctor if you have unlikely but serious side effects of Prostigmin including:
- new or increased muscle cramps/weakness/twitching,
- new or increased difficulty swallowing,
- slow/fast/irregular heartbeat,
- shortness of breath,
- headache, or
Dosage requirements of Prostigmin for optimal results vary from 15 mg to 375 mg per day. Prostigmin may interact with atropine, belladonna, clidinium, dicyclomine, glycopyrrolate, hyoscyamine, mepenzolate, methantheline, methscopolamine, propantheline, scopolamine, antibiotics, or heart rhythm medications. Tell your doctor all medications you use. During pregnancy, Prostigmin should be used only when prescribed. It is unknown if this drug passes into breast milk. Similar drugs pass into breast milk. Consult your doctor before breastfeeding.
Our Prostigmin (neostigmine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: new or increased muscle cramps/weakness/twitching, new or increased difficulty swallowing, slow/fast/irregular heartbeat, dizziness, shortness of breath, headache, seizures.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Prostigmin (Neostigmine)
The following additional adverse reactions have been reported following the use of either neostigmine bromide or neostigmine methylsulfate:
Allergic: Allergic reactions and anaphylaxis.
Cardiovascular: Cardiac arrhythmias (including bradycardia, tachycardia, A-V block and nodal rhythm) and nonspecific EKG changes have been reported, as well as cardiac arrest, syncope and hypotension. These have been predominantly noted following the use of the injectable form of Prostigmin (neostigmine) .
Respiratory: Increased oral, pharyngeal and brochial secretions, and dyspnea. Respiratory depression, respiratory arrest and bronchospasm have been reported following the use of the injectable form of Prostigmin (neostigmine) .
Genitourinary: Urinary frequency.
Miscellaneous: Diaphoresis, flushing and weakness.
Read the entire FDA prescribing information for Prostigmin (Neostigmine)