Provigil vs. Sunosi

Reviewed on 4/14/2021

Are Provigil and Sunosi the Same Thing?

Provigil (modafinil) and Sunosi (solriamfetol) are used to increase wakefulness in patients with excessive sleepiness related to narcolepsy, shiftwork sleep disorder, and obstructive sleep apnea/hypopnea syndrome.

Provigil is also used to increase wakefulness in patients with excessive sleepiness related to shiftwork sleep disorder.

Provigil and Sunosi belong to different drug classes. Provigil is a stimulant and Sunosi is a dopamine and norepinephrine reuptake inhibitor (DNRI).

Side effects of Provigil and Sunosi that are similar include headache, nausea, anxiety, and trouble sleeping (insomnia).

Side effects of Provigil that are different from Sunosi include dizziness, upper respiratory tract infection, diarrhea, nervousness, agitation, and dry mouth.

Side effects of Sunosi that are different from Provigil include decreased appetite.

Provigil may interact with cyclosporine, theophylline, hormonal contraceptives, warfarin, diazepam, propranolol, imipramine, desipramine, phenytoin, carbamazepine, rifampin, ketoconazole, and itraconazole.

Sunosi may interact with monoamine oxidase inhibitors (MAOIs), other drugs that increase blood pressure and/or heart rate, and dopaminergic drugs.

What Are Possible Side Effects of Provigil?

Common side effects of Provigil include:

  • headache,
  • dizziness,
  • upper respiratory tract infection,
  • nausea,
  • diarrhea,
  • nervousness,
  • anxiety,
  • agitation,
  • dry mouth, and
  • trouble sleeping (insomnia).

Tell your doctor if you experience serious side effects of Provigil including:

  • fever,
  • easy bruising or bleeding,
  • hallucinations,
  • depression,
  • chest pain,
  • fast/pounding/irregular heartbeat, or
  • mental/mood changes (such as confusion, depression, hallucinations, rare thoughts of suicide).

What Are Possible Side Effects of Sunosi?

Common side effects of Sunosi include:

  • headache,
  • nausea,
  • decreased appetite,
  • insomnia, and
  • anxiety

What Is Provigil?

Provigil (modafinil) is a stimulant prescribed to increase wakefulness in patients with excessive sleepiness related to narcolepsy, shiftwork sleep disorder, and obstructive sleep apnea/hypopnea syndrome.

QUESTION

Why do we sleep? See Answer

What Is Sunosi?

Sunosi (solriamfetol) is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated to improve wakefulness in adult patients with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea (OSA).

What Drugs Interact With Provigil?

Provigil drug interactions include cyclosporine (Sandimmune), theophylline (Theo-24), hormonal contraceptives (for example, Micronor), warfarin (Coumadin), diazepam (Valium), propranolol (Inderal), imipramine (Tofranil), desipramine (Norpramin), phenytoin (Dilantin), carbamazepine (Tegretol), rifampin (Rifadin), Ketoconazole (Nizoral) and itraconazole (Sporanox). Provigil has not been adequately studied in pregnant women and it is unknown if it is excreted in breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Sunosi?

Sunosi may interact with monoamine oxidase inhibitors (MAOIs), other drugs that increase blood pressure and/or heart rate, and dopaminergic drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Sunosi; it is unknown how it would affect a fetus. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Sunosi during pregnancy. It is unknown if Sunosi passes into breast milk. Consult your doctor before breastfeeding.

How Should Provigil be Taken?

Provigil dosage is 200 or 400 mg daily.

How Should Sunosi be Taken?

Sunosi is administered once daily upon awakening. The starting dose of Sunosi for patients with narcolepsy is 75 mg once daily. The starting dose of Sunosi for patients with OSA is 37.5 mg once daily.

SLIDESHOW

Sleep Disorders: Foods That Help Sleep or Keep You Awake See Slideshow
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Teva Pharmaceuticals. Provigil Production Information.

https://www.provigil.com/

Jazz Pharmaceuticals Inc. Sunosi Product Information.

https://www.sunosi.com

Health Solutions From Our Sponsors