Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 3/14/2022
Provocholine Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Provocholine?

Provocholine (methacholine chloride) is a cholinergic drug that causes wheezing and shortness of breath and is used as a test to determine whether you may have asthma. Provocholine is only administered in a clinical setting and is used for testing and not to treat any conditions.

What Are Side Effects of Provocholine?

Common side effects of Provocholine include:

Dosage for Provocholine

Before Provocholine inhalation challenge is begun baseline pulmonary function tests must be performed. The dose needed for testing will be determined by your physician.

What Drugs, Substances, or Supplements Interact with Provocholine?

Provocholine may interact with beta-blockers or asthma drugs. Tell your doctor all medications and supplements you use.

Provocholine During Pregnancy and Breastfeeding

During pregnancy Provocholine should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Provocholine (methacholine chloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Provocholine Consumer Information
SIDE EFFECTS: Headache, sore throat, lightheadedness, nausea, vomiting, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these serious side effects occur: trouble breathing, cough, wheezing, chest pain/tightness, irregular heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Provocholine (Methacholine Chloride)


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Provocholine Professional Information


The following adverse reactions associated with the use of Provocholine were identified in clinical studies or post marketing reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Bronchospasm (includes symptoms such as chest tightness, cough or wheezing).

Adverse reactions less commonly associated with Provocholine include headache, throat irritation, light-headedness and itching.

Read the entire FDA prescribing information for Provocholine (Methacholine Chloride)

© Provocholine Patient Information is supplied by Cerner Multum, Inc. and Provocholine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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