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Pulmonary Embolism (cont.)

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Thrombolytic therapy

Pulmonary embolism can be fatal, especially if there is a large amount of clot present within the pulmonary arteries. Tissue plasminogen activator (tPA) is a medication given to break up blood clots, known as thrombolytic therapy. Thrombolytic therapy with tPA is indicated in patients with pulmonary emboli who also have hypotension (low blood pressure), since this may be one sign of shock. Others signs of shock include:

  • confusion,
  • coma, or
  • damage to other organs including the heart and kidneys.

tPA helps break up or dissolve the arterial clot. It may be given peripherally in an IV or centrally, through a catheter that is inserted in the arm or groin and threaded into the pulmonary artery, so that the medication can be delivered directly to the clot. Evidence of right heart strain on CT scan or by echocardiogram, or blood tests that show the heart to be under strain (for example, troponin levels), also may be an indication for thrombolytic therapy, depending upon the clinical situation.

Thrombolytic therapy with tPA is an emergent treatment that thins the blood immediately. Warfarin and factor X inhibitors are not prescribed immediately in this situation, though unfractionated heparin may be used initially while decisions regarding the use of tPA are considered.

What is the prognosis for pulmonary embolism?

Patient survival depends upon:

  • the underlying health of the patient,
  • size of the pulmonary embolus,
  • the cause of the pulmonary embolus, and
  • the ability for a diagnosis to be made and treatment initiated.

The diagnosis is often difficult, and it is estimated to that there are up to 400,000 cases of pulmonary embolus that are not diagnosed in the United States each year.

In those patients where the diagnosis is made, the death (mortality) rate is less than 20% when considering all patients. Usually, however, the mortality risk is much less in most patients. The higher incidence of death occurs in patients that are older, have other underlying illnesses, or have a delay in diagnosis. Racial differences may also exist, but probably are due more to access to quality care than a specific genetic difference.

Can pulmonary embolism be prevented?

Minimizing the risk of deep vein thrombosis minimizes the risk of pulmonary embolism. The embolism cannot occur without the initial DVT.

  • In the hospital setting, the nursing staff works hard to minimize the potential for clot formation in immobilized patients. Compression stockings are routinely used. Surgery patients are out of bed walking (ambulatory) earlier and low dose heparin or enoxaparin is being used for deep vein thrombosis prophylaxis (measures taken to prevent deep vein thrombosis).
  • For those who travel, it is recommended that they get up and walk every couple of hours during a long trip.
  • Compression stockings may be helpful in preventing future deep vein thrombus formation in patients with a previous history of a clot.
  • Smoking is a risk factor for DVT formation, especially in women who are on the birth control pill.


Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2_suppl):e737S-e801S. doi:10.1378/chest.11-2308.

Carman, tl, Gegaj F Management of Pulmonary Embolism: 2010 State of the Art Update Curr Treat Options. Cardiovasc Med. 2010 Apr;12(2);168-184

Giancarlo, A., et al. "Apixaban for Extended Treatment of Venous Thromboembolism." New England Journal of Medicine. 368 (2013): 699-708.

Kline, JA et al. Prospective multicenter evaluation of the pulmonary embolus rule-out criteria. J Thromb Haemost. 2008 May, 6(5).

Pollack, C.V., et al. "Idarucizumab for Dabigatran Reversal." New England Journal of Medicine. 373.6 (2015): 511-520.

Tintinalli J, etal. Tintinalli's Emergency Medicine: A Comprehensive Study Guide. 7th edition. McGraw-Hill Professional 2010.

Medically Reviewed by a Doctor on 11/20/2015


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