Last updated on RxList: 4/27/2021
Pyrazinamide Side Effects Center

What Is Pyrazinamide?

Pyrazinamide is an antibiotic used to treat tuberculosis (TB). Pyrazinamide is available in generic form.

What Are Side Effects of Pyrazinamide?

Common side effects of pyrazinamide include:

Tell your doctor if you have unlikely but serious side effects of pyrazinamide including:

Dosage for Pyrazinamide

The usual dose of Pyrazinamide is 15 to 30 mg/kg once daily, taken orally. It should always be administered with other effective anti-tuberculosis drugs. It is administered for the initial 2 months of a 6-month or longer treatment regimen for drug-susceptible patients.

What Drugs, Substances, or Supplements Interact with Pyrazinamide?

Pyrazinamide may interact with allopurinol, or Acetest and Ketostix urine tests for ketones. Other drugs may interact with pyrazinamide. Tell your doctor all prescription or over-the-counter medicines and supplements you use.

Pyrazinamide During Pregnancy or Breastfeeding

During pregnancy, Pyrazinamide should be used only when prescribed. This medication passes into breast milk but the effect on a nursing infant is unknown. Consult your doctor before breastfeeding.

Additional Information

Our Pyrazinamide Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Pyrazinamide Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fever;
  • joint pain or swelling;
  • easy bruising or bleeding (nosebleeds, bleeding gums);
  • gout flare-up symptoms--joint pain, stiffness, redness, or swelling (especially at night); or
  • liver problems--nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • joint or muscle pain;
  • nausea, vomiting; or
  • loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Pyrazinamide (Pyrazinamide)


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Pyrazinamide Professional Information


General: Fever, porphyria and dysuria have rarely been reported. Gout (see PRECAUTIONS).

Gastrointestinal: The principal adverse effect is a hepatic reaction (see WARNINGS). Hepatotoxicity appears to be dose related, and may appear at any time during therapy. Gl disturbances including nausea, vomiting and anorexia have also been reported.

Hematologic and Lymphatic: Thrombocytopenia and sideroblastic anemia with erythroid hyperplasia, vacuolation of erythrocytes and increased serum iron concentration have occurred rarely with this drug. Adverse effects on blood clotting mechanisms have also been rarely reported.

Other: Mild arthralgia and myalgia have been reported frequently. Hypersensitivity reactions including rashes, urticaria, and pruritis have been reported. Fever, acne, photosensitivity, porphyria, dysuria and interstitial nephritis have been reported rarely.

Read the entire FDA prescribing information for Pyrazinamide (Pyrazinamide)

© Pyrazinamide Patient Information is supplied by Cerner Multum, Inc. and Pyrazinamide Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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