Quinidine Gluconate Side Effects Center

Last updated on RxList: 8/1/2022
Quinidine Gluconate Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Quinidine Gluconate?

Quinidine Gluconate (quinidine) is an antiarrhythmic medication that is used to correct disturbances in the rhythm of the heart. Quinidine gluconate is available in generic form.

What Are Side Effects of Quinidine Gluconate?

Common side effects of quinidine gluconate include:

Quinidine Gluconate may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • severe dizziness,
  • fainting,
  • fast, slower, or irregular heartbeat,
  • vision changes,
  • eye pain,
  • muscle pain,
  • unusual sweating,
  • shakiness,
  • fever,
  • persistent sore throat,
  • easy bruising,
  • unusual bleeding,
  • extreme tiredness,
  • dark urine,
  • persistent nausea or vomiting,
  • yellowing eyes or skin (jaundice),
  • joint or muscle pain,
  • chest pain,
  • changes in the amount of urine,
  • rash,
  • itching,
  • ringing in the ears,
  • sudden hearing problems,
  • headache,
  • blurred vision, and
  • confusion

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Quinidine Gluconate

Quinidine gluconate is taken orally in tablet form. The dosage varies considerably depending upon the general condition and the cardiovascular state of the patient. Take this medication by mouth with or without food with a full glass of liquid (8 ounces/240 milliliters) as directed by your doctor. Quinidine Gluconate is best taken on an empty stomach, but taking it with food may help decrease stomach upset. Do not lie down for 10 minutes after taking this medication.

What Drugs, Substances, or Supplements Interact with Quinidine Gluconate?

Quinidine Gluconate may interact with other drugs, so tell your doctor all medications you use. Avoid grapefruit or grapefruit juice while taking Quinidine Gluconate.

Quinidine Gluconate During Pregnancy or Breastfeeding

If you are pregnant, only take Quinidine Gluconate if the potential benefit outweighs the potential risk to the fetus. Consult your doctor before using Quinidine Gluconate if you are breastfeeding.

Additional Information

Our Quinidine Gluconate (quinidine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Quinidine Gluconate Professional Information

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Quinidine preparations have been used for many years, but there are only sparse data from which to estimate the incidence of various adverse reactions. The adverse reactions most frequently reported have consistently been gastrointestinal, including diarrhea, nausea, vomiting, and heartburn/esophagitis.

In the reported study that was closest in character to the predominant approved use of quinidine gluconate, 86 adult outpatients with atrial fibrillation were followed for six months while they received slow-release quinidine bisulfate tablets, 600 mg (approximately 400 mg of quinidine base) twice daily. The incidences of adverse experiences reported more than once were as shown in the table below. The most serious quinidine-associated adverse reactions are described above under WARNINGS.


  Incidence (%)
diarrhea 21 (24%)
fever 5 (6%)
rash 5 (6%)
arrhythmia 3 (3%)
abnormal electrocardiogram 3 (3%)
nausea/vomiting 3 (3%)
dizziness 3 (3%)
headache 3 (3%)
asthenia 2 (2%)
cerebral ischemia 2 (2%)

Vomiting and diarrhea can occur as isolated reactions to therapeutic levels of quinidine, but they may also be the first signs of cinchonism, a syndrome that may also include tinnitus, reversible high-frequency hearing loss, deafness, vertigo, blurred vision, diplopia, photophobia, headache, confusion, and delirium. Cinchonism is most often a sign of chronic quinidine toxicity, but it may appear in sensitive patients after a single moderate dose.

A few cases of hepatotoxicity, including granulomatous hepatitis, have been reported in patients receiving quinidine. All of these have appeared during the first few weeks of therapy, and most (not all) have remitted once quinidine was withdrawn.

Autoimmune and inflammatory syndromes associated with quinidine therapy have included fever, urticaria, flushing, exfoliative rash, bronchospasm, psoriasiform rash, pruritus and lymphadenopathy, hemolytic anemia, vasculitis, thrombocytopenic purpura, uveitis, angioedema, agranulocytosis, the sicca syndrome, arthralgia, myalgia, elevation in serum levels of skeletal-muscle enzymes, a disorder resembling systemic lupus erythematosus, and pneumonitis.

Convulsions, apprehension, and ataxia have been reported, but it is not clear that these were not simply the results of hypotension and consequent cerebral hypoperfusion. There are many reports of syncope. Acute psychotic reactions have been reported to follow the first dose of quinidine, but these reactions appear to be extremely rare.

Other adverse reactions occasionally reported include depression, mydriasis, disturbed color perception, night blindness, scotomata, optic neuritis, visual field loss, photosensitivity, and abnormalities of pigmentation.

Read the entire FDA prescribing information for Quinidine Gluconate (Quinidine Gluconate)


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© Quinidine Gluconate Patient Information is supplied by Cerner Multum, Inc. and Quinidine Gluconate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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