Relafen vs. Norco

Are Relafen and Norco the Same Thing?

Relafen (nabumetone) and Norco (hydrocodone bitartrate and acetaminophen) are used to treat pain.

Relafen is used to treat inflammation and pain caused by arthritis.

Norco is used to treat moderate to fairly severe pain.

Relafen and Norco belong to different drug classes. Relafen is a nonsteroidal anti-inflammatory drug (NSAID) and Norco is an opioid analgesic and antitussive (cough suppressant) combined with a pain reliever (analgesic).

The brand name Relafen is no longer available in the U.S. Generic versions may be available.

Side effects of Relafen and Norco that are similar include upset stomach, constipation, dizziness, headache, blurred vision, and ringing in your ears.

Side effects of Relafen that are different from Norco include heartburn, stomach pain, diarrhea, bloating, gas, nervousness, and skin itching or rash.

Side effects of Norco that are different from Relafen include anxiety, drowsiness, lightheadedness, nausea, vomiting, mood changes, or dry mouth.

Both Relafen and Norco may interact with alcohol and antidepressants.

Relafen may also interact with blood thinners, lithium, methotrexate, heart or blood pressure medications, diuretics (water pills), steroids, aspirin or other NSAIDs, or ACE inhibitors.

Norco may also interact with other narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, other medicines that can make you sleepy or slow your breathing, MAO inhibitors, atropine, benztropine, dimenhydrinate, glycopyrrolate, mepenzolate, methscopolamine, scopolamine, bladder or urinary medications, bronchodilators, or irritable bowel medications.

Withdrawal symptoms may occur if you suddenly stop taking Norco.

What Are Possible Side Effects of Relafen?

Common side effects of Relafen include:

  • upset stomach,
  • heartburn,
  • stomach pain,
  • diarrhea,
  • constipation,
  • bloating,
  • gas,
  • dizziness,
  • headache,
  • nervousness,
  • skin itching or rash,
  • blurred vision, or
  • ringing in your ears.

Nonsteroidal anti-inflammatory drugs (including Relafen) may rarely increase the risk for a heart attack or stroke. Bleeding from the gastrointestinal tract is another potentially serious side effect of Relafen.

What Are Possible Side Effects of Norco?

Common side effects of Norco include:

  • anxiety,
  • dizziness,
  • drowsiness,
  • lightheadedness,
  • nausea,
  • vomiting,
  • upset stomach,
  • constipation,
  • headache,
  • mood changes,
  • blurred vision,
  • ringing in your ears, or
  • dry mouth.

What Is Relafen?

Relafen (nabumetone) is a nonsteroidal anti-inflammatory (NSAID) drug used to treat inflammation and pain caused by arthritis. The brand name drug Relafen is no longer available in the U.S. Generic versions may be available.

What Is Norco?

Norco is a strong prescription medicine is indicated for the relief of moderate to moderately severe pain.

What Drugs Interact With Relafen?

Relafen may interact with antidepressants, blood thinners, lithium, methotrexate, diuretics (water pills), steroids, aspirin or other NSAIDs, or ACE inhibitors.. There are no adequate, well-controlled studies in pregnant women, and Relafen should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Use during late pregnancy should be avoided because of the known effects of NSAIDs in the fetal cardiovascular system (closure of ductus arteriosus). It is not known whether Relafen is excreted in human milk; a decision should be made whether to discontinue breastfeeding or to discontinue the Relafen.

What Drugs Interact With Norco?

Norco, like all narcotics, may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery; patients should be cautioned accordingly.

Alcohol and other CNS depressants may produce an additive CNS depression, when taken with this combination product, and should be avoided.

Hydrocodone may be habit-forming. Patients should take the drug only for as long as it is prescribed, in the amounts prescribed, and no more frequently than prescribed.

How Should Relafen Be Taken?

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

How Should Norco Be Taken?

Dosage should be adjusted according to the severity of the pain and the response of the patient. However, it should be kept in mind that tolerance to hydrocodone can develop with continued use and that the incidence of untoward effects is dose related.

The usual adult dosage is one or two tablets every four to six hours as needed for pain. The total daily dosage should not exceed 8 tablets.


All drug information provided on is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, makes every effort to update its drug information. Due to the time-sensitive nature of drug information, makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the or websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.


FDA. Relafen Product Information.

Allergan. Norco Prescribing Information.

Health Solutions From Our Sponsors