Relafen vs. Zipsor, Zorvolex

Are Relafen and Zipsor, Zorvolex the Same Thing?

Relafen (nabumetone) and Zipsor and Zorvolex (diclofenac) are nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain.

Relafen us often used to treat inflammation and pain caused by arthritis while Zipsor and Zorvolex are used for relief of mild to moderate acute pain.

The brand name Relafen is no longer available in the U.S. Generic versions may be available.

Side effects of Relafen and Zipsor and Zorvolex that are similar include heartburn/indigestion, stomach/abdominal pain, diarrhea, constipation, gas, dizziness, headache, and skin itching.

Side effects of Relafen that are different from Zipsor and Zorvolex include upset stomach, bloating, nervousness, rash, blurred vision, or ringing in your ears.

Side effects of Zipsor and Zorvolex that are different from Relafen include arthritis, back pain, cough, drowsiness, high or low blood pressure, increased sweating, nausea, pain in extremities, runny or stuffy nose, sinus infection, fluid retention (edema), upper respiratory tract infection, urinary tract infection (UTI), and vomiting.

Both Relafen and Zipsor and Zorvolex may interact with alcohol, antidepressants, blood thinners, aspirin or other NSAIDs, heart or blood pressure medications, diuretics (water pills), lithium, methotrexate, steroids, or ACE inhibitors.

Zipsor and Zorvolex may also interact with digoxin, cyclosporine, pemetrexed, voriconazole, and rifampin.

What Are Possible Side Effects of Relafen?

Common side effects of Relafen include:

  • upset stomach,
  • heartburn,
  • stomach pain,
  • diarrhea,
  • constipation,
  • bloating,
  • gas,
  • dizziness,
  • headache,
  • nervousness,
  • skin itching or rash,
  • blurred vision, or
  • ringing in your ears.

Nonsteroidal anti-inflammatory drugs (including Relafen) may rarely increase the risk for a heart attack or stroke. Bleeding from the gastrointestinal tract is another potentially serious side effect of Relafen.

What Are Possible Side Effects of Zipsor, Zorvolex?

Common side effects of Zipsor, Zorvolex include:

  • abdominal pain,
  • constipation,
  • diarrhea,
  • indigestion,
  • nausea,
  • vomiting,
  • dizziness,
  • headache,
  • drowsiness,
  • itching, and
  • increased sweating

What Is Relafen?

Relafen (nabumetone) is a nonsteroidal anti-inflammatory (NSAID) drug used to treat inflammation and pain caused by arthritis. The brand name drug Relafen is no longer available in the U.S. Generic versions may be available.

What Is Zipsor, Zorvolex?

Zipsor, Zorvolex (diclofenac potassium) Liquid Filled Capsules is a nonsteroidal anti-inflammatory drug (NSAID) indicated for relief of mild to moderate acute pain.


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What Drugs Interact With Relafen?

Relafen may interact with antidepressants, blood thinners, lithium, methotrexate, diuretics (water pills), steroids, aspirin or other NSAIDs, or ACE inhibitors.. There are no adequate, well-controlled studies in pregnant women, and Relafen should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Use during late pregnancy should be avoided because of the known effects of NSAIDs in the fetal cardiovascular system (closure of ductus arteriosus). It is not known whether Relafen is excreted in human milk; a decision should be made whether to discontinue breastfeeding or to discontinue the Relafen.

What Drugs Interact With Zipsor, Zorvolex?

Zipsor, Zorvolex may interact with aspirin and anticoagulants.

Tell your doctor all medications and supplements you use. Zipsor is not recommended for use during pregnancy; it may harm a fetus. Starting at 30 weeks gestation, Zipsor should be avoided. It is unknown if Zipsor passes into breast milk. Consult your doctor before breastfeeding.

How Should Relafen Be Taken?

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

How Should Zipsor, Zorvolex Be Taken?

The dosage of Zipsor, Zorvolex is 25 mg four times a day.


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FDA. Relafen Product Information.

Depomed. Zipsor Prescribing Information.

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