Slideshows Images Quizzes

Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.


Last reviewed on RxList: 4/6/2020
Relpax Side Effects Center

What Is Relpax?

Relpax (eletriptan hydrobromide) is a selective serotonin receptor agonist used to treat migraine headaches. Relpax will only treat a headache that has already begun. Relpax will not prevent headaches or reduce the number of attacks.

What Are Side Effects of Relpax?

Common side effects of Relpax include:

  • mild headache (not a migraine),
  • tingling/numbness,
  • nausea,
  • upset stomach,
  • stomach pain or cramps,
  • weakness,
  • drowsiness,
  • dizziness,
  • pressure or heavy feeling in any part of your body,
  • dry mouth, or
  • flushing (warmth, redness, or tingling under your skin).

Tell your doctor if you have serious side effects of Relpax including:

Dosage for Relpax

A single dose of 20 mg or 40 mg is effective for the acute treatment of migraine in adults. After taking Relpax, you must wait 2 hours before taking another dose.

What Drugs, Substances, or Supplements Interact with Relpax?

Relpax should not be used with sibutramine because a very serious interaction may occur. Relpax should not be used within 72 hours of use of drugs affecting liver enzymes that remove eletriptan from your body such as nefazodone, azole antifungals, antibiotics, and protease inhibitors. Relpax should not be used within 24 hours of use of ergot-type drugs or other migraine drugs because of serious interactions. Antidepressants, St. John's wort, antihistamines, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, narcotic pain relievers, and psychiatric medicines may all adversely interact with this drug. Discuss all medications you are taking with your doctor.

Relpax During Pregnancy and Breastfeeding

During pregnancy, this medication should be used only when prescribed by your doctor. This drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Relpax Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


16 Surprising Headache Triggers and Tips for Pain Relief See Slideshow
Relpax Consumer Information

3 pharmacies near 20147 have coupons for Relpax (Brand Names:Relpax for 6 Tablets)

CVS Pharmacy
CVS Pharmacy

Est. Regular Price


with free coupon

View Coupon

Est. Regular Price


with free coupon

View Coupon
Harris Teeter Pharmacy
Harris Teeter Pharmacy

Est. Regular Price


with free coupon

View Coupon

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast, slow, or uneven heart rate;
  • sudden severe stomach pain (especially after meals), constipation or diarrhea, weight loss;
  • fever, diarrhea that is bloody;
  • numbness, tingling, cold feeling or burning pain in your feet or toes;
  • tightness or heavy feeling in your legs, pale or blue-colored appearance in your fingers or toes;
  • severe headache, blurred vision, pounding in your neck or ears; or
  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Stop using eletriptan and call your doctor at once if you have:

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects may include:

  • dizziness, drowsiness;
  • nausea; or
  • weakness, feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Relpax (Eletriptan hydrobromide)


Who suffers more frequently from migraine headaches? See Answer
Relpax Professional Information


The following adverse reactions are described elsewhere in other sections of the prescribing information:

  • Myocardial ischemia and myocardial infarction, and Prinzmetal's angina [see WARNINGS AND PRECAUTIONS]
  • Arrhythmias [see WARNINGS AND PRECAUTIONS]
  • Chest, throat, neck, and/or jaw pain/tightness/pressure [see WARNINGS AND PRECAUTIONS]
  • Cerebrovascular events [see WARNINGS AND PRECAUTIONS]
  • Other vasospasm reactions [see WARNINGS AND PRECAUTIONS]
  • Medication overuse headache [see WARNINGS AND PRECAUTIONS]
  • Serotonin syndrome [see WARNINGS AND PRECAUTIONS]
  • Increase in blood pressure [see WARNINGS AND PRECAUTIONS]
  • Hypersensitivity reactions [see CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS]

Clinical Trials Experience

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.

Among 4,597 patients who treated the first migraine headache with RELPAX in short-term placebo-controlled trials, the most common adverse reactions reported with treatment with RELPAX were asthenia, nausea, dizziness, and somnolence. These reactions appear to be dose-related.

In long-term open-label studies where patients were allowed to treat multiple migraine attacks for up to 1 year, 128 (8.3%) out of 1,544 patients discontinued treatment due to adverse reactions.

Table 1 lists adverse reactions that occurred in the subset of 5,125 migraineurs who received eletriptan doses of 20 mg, 40 mg and 80 mg or placebo in worldwide placebo-controlled clinical trials.

Only adverse reactions that were more frequent in a RELPAX treatment group compared to the placebo group with an incidence greater than or equal to 2% are included in Table 1.

Table 1: Adverse Reactions Incidence in Placebo-Controlled Migraine Clinical Trials: Reactions Reported by ≥ 2% Patients Treated with RELPAX and More Than Placebo

Adverse Reaction TypePlacebo
RELPAX 20 mg
RELPAX 40 mg
RELPAX 80 mg
Flushing/feeling of warmth2%2%2%2%
Chest - tightness/pain/pressure1%1%2%4%
Abdominal - pain/discomfort/stomach pain/ cramps/pressure1%1%2%2%
Dry mouth2%2%3%4%
Dysphagia - throat tightness/difficulty swallowing0.2%1%2%2%

The frequency of adverse reactions in clinical trials did not increase when up to 2 doses of RELPAX were taken within 24 hours. The incidence of adverse reactions in controlled clinical trials was not affected by gender, age, or race of the patients. Adverse reaction frequencies were also unchanged by concomitant use of drugs commonly taken for migraine prophylaxis (e.g., SSRIs, beta blockers, calcium channel blockers, tricyclic antidepressants), estrogen replacement therapy or oral contraceptives.

Postmarketing Experience

The following adverse reaction(s) have been identified during post approval use of RELPAX. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Neurological: seizure Digestive: vomiting

Read the entire FDA prescribing information for Relpax (Eletriptan hydrobromide)

Related Resources for Relpax

Related Health

Read the Relpax User Reviews »

© Relpax Patient Information is supplied by Cerner Multum, Inc. and Relpax Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.


16 Surprising Headache Triggers and Tips for Pain Relief See Slideshow

Health Solutions From Our Sponsors