Restoril vs. Trazodone, Oleptro

Are Restoril and Trazodone, Oleptro the Same Thing?

Restoril (temazepam) and Trazodone, Oleptro are used to treat insomnia symptoms.

Trazodone, Oleptro are used off-label to treat insomnia. It is primarily used to treat depression.

Restoril and Trazodone, Oleptro belong to different drug classes. Restoril is a benzodiazepine sedative hypnotic and trazodone is an antidepressant.

Side effects of Restoril and Trazodone, Oleptro that are similar include dizziness, drowsiness, headache, blurred vision, nausea, vomiting, or dry mouth.

Side effects of Restoril that are different from trazodone include amnesia or forgetfulness, muscle weakness, loss of balance or coordination, depression, nervousness, excitability, irritability, stomach discomfort, increased thirst, or numbness, burning, pain, or, tingly feeling.

Side effects of Trazodone, Oleptro that are different from Restoril include diarrhea, tiredness, changes in weight, muscle ache/pain, bad taste in the mouth, stuffy nose, constipation, or changes in sexual interest/ability.

Both Restoril and Trazodone, Oleptro may interact with alcohol or other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety).

Restoril may also interact with itraconazole or ketoconazole.

Trazodone, Oleptro may also interact with St. John's wort, tramadol, diuretics (water pills), medicines to treat mental illness, blood thinners, or migraine headache medicines.

Withdrawal symptoms may occur if you suddenly stop taking Restoril.

What Are Possible Side Effects of Restoril?

Common side effects of Restoril include:

  • dizziness
  • daytime drowsiness (or during hours when you are not normally sleeping)
  • amnesia or forgetfulness
  • muscle weakness
  • loss of balance or coordination
  • headache
  • blurred vision
  • depression
  • nervousness
  • excitability
  • irritability
  • nausea
  • vomiting
  • stomach discomfort
  • dry mouth
  • increased thirst, or
  • numbness
  • burning
  • pain, or
  • tingly feeling

Tell your doctor if you experience serious side effects of Restoril including weak or shallow breathing, fast or pounding heartbeats, confusion, slurred speech, unusual thoughts or behavior, hallucinations, agitation, aggression, thoughts of suicide or hurting yourself, restless muscle movements (in your eyes, tongue, jaw, or neck), pale skin, easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms, problems with urination, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

What Are Possible Side Effects of Trazodone, Oleptro?

Common side effects of Trazodone, Oleptro include:

  • drowsiness,
  • sedation,
  • dizziness,
  • lightheadedness,
  • constipation,
  • headache,
  • blurred vision,
  • nausea,
  • vomiting,
  • dry mouth, or
  • change in sexual interest/ability.

Tell your doctor if you have serious side effects of Trazodone, Oleptro including:

  • extreme mood swings,
  • restlessness,
  • sleep problems,
  • dizziness,
  • fainting,
  • fast or pounding heartbeat,
  • easy bruising or bleeding,
  • agitation,
  • hallucinations,
  • fast heart rate,
  • overactive reflexes,
  • diarrhea,
  • loss of coordination,
  • very stiff (rigid) muscles,
  • high fever,
  • confusion,
  • fast or uneven heartbeats,
  • tremors,
  • trouble concentrating,
  • memory problems,
  • weakness,
  • loss of appetite,
  • unsteadiness,
  • seizures,
  • shallow breathing or breathing that stops,
  • chest pain or heavy feeling,
  • pain spreading to the arm or shoulder,
  • nausea,
  • sweating, or
  • general ill feeling (malaise).

What Is Restoril?

Restoril (temazepam) is a benzodiazepine sedative hypnotic used to treat insomnia symptoms, such as trouble falling or staying asleep. Restoril is available in generic form.

What Is Trazodone, Oleptro?

Trazodone, Oleptro (trazodone hydrochloride extended-release tablets) is a triazolopyridine antidepressant used to treat major depressive disorder (MDD) in adults.

What Drugs Interact With Restoril?

Restoril may interact with fluvoxamine, itraconazole, ketoconazole, nefazodone, or other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). Tell your doctor all medication you use. Restoril must not be used during pregnancy. Other medications in this class have caused birth defects when used in the first three months of pregnancy, and have also caused unusual drowsiness, feeding problems, and liver problems in newborns when used at or near the time of delivery, or withdrawal symptoms in newborns when used for a long time during pregnancy. Use birth control while taking this drug. This medication passes into breast milk. Consult your doctor before breast-feeding. Withdrawal symptoms (such as unusual depressed/anxious mood, stomach/muscle cramps, vomiting, sweating, shakiness, seizures) may occur if you suddenly stop using this medication.

What Drugs Interact With Trazodone, Oleptro?

Trazodone, Oleptro may interact with monoamine oxidase inhibitors (MAOIs), alcohol, barbiturates, other CNS depressants, ritonavir, ketoconazole, indinavir, itraconazole, carbamazepine, digoxin, phenytoin, serotonergic drugs, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, other drugs affecting coagulation or bleeding, or warfarin. Tell your doctor all medications you use. During pregnancy, Oleptro should be used only if prescribed. This medication may be passed in breast milk. Consult your doctor before breastfeeding.

How Should Restoril Be Taken?

The recommended dose of Restoril is 40 to 320 mcg twice daily for adults and 40 to 80 mcg twice daily for children. If you are also using a bronchodilator, use it first before using the beclomethasone inhaler. There may be other drugs that can interact with Restoril.

How Should Trazodone, Oleptro Be Taken?

The recommended starting dose of Trazodone, Oleptro is 150 mg once daily in adults. The dose may be increased by 75 mg/day every three days (i.e., start 225 mg on Day 4 of therapy). The maximum daily dose should not exceed 375 mg.


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FDA. Restoril Product Information.

FDA. Oleptro Product Information

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