Retevmo vs. Gavreto

Reviewed on 12/3/2020

Are Retevmo and Gavreto the Same Thing?

Retevmo (selpercatinib) and Gavreto (pralsetinib) are kinase inhibitors used to treat adult patients with metastatic rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC).

Retevmo is also used to treat adult and pediatric patients 12 years of age and older with advanced or metastatic RET-mutant medullary thyroid cancer (MTC) who require systemic therapy, and adult and pediatric patients 12 years of age and older with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and who are radioactive iodine-refractory (if radioactive iodine is appropriate).

Side effects of Retevmo and Gavreto that are similar include increased alanine aminotransferase (ALT), decreased calcium, dry mouth, decreased sodium, diarrhea, fatigue, fluid retention (edema), high blood pressure (hypertension), and constipation.

Side effects of Retevmo that are different from Gavreto include increased aspartate aminotransferase (AST), increased blood sugar (glucose), decreased leukocytes, decreased albumin, increased creatinine, increased alkaline phosphatase, decreased platelets, increased total cholesterol, and rash.

Side effects of Gavreto that are different from Retevmo include musculoskeletal pain, fever, cough, pneumonia, decreased lymphocytes, decreased neutrophils, decreased phosphate, and decreased hemoglobin.

Both Retevmo and Gavreto may interact with strong and moderate CYP3A inhibitors or inducers.

Retevmo may also interact with acid-reducing agents (such as proton pump inhibitors, H2 receptor antagonists, and locally-acting antacids), CYP2C8 and CYP3A substrates, and medications known to prolong the QT interval.

Gavreto may also interact with combined P-gp and strong CYP3A inhibitors.

What Are Possible Side Effects of Retevmo?

Common side effects of Retevmo include:

  • increased aspartate aminotransferase (AST),
  • increased alanine aminotransferase (ALT),
  • increased blood sugar (glucose),
  • decreased leukocytes,
  • decreased albumin,
  • decreased calcium,
  • dry mouth,
  • diarrhea,
  • increased creatinine,
  • increased alkaline phosphatase,
  • high blood pressure (hypertension),
  • fatigue,
  • fluid retention (edema),
  • decreased platelets,
  • increased total cholesterol,
  • rash,
  • decreased sodium, and
  • constipation

What Are Possible Side Effects of Gavreto?

Common side effects of Gavreto include:

  • fatigue,
  • constipation,
  • musculoskeletal pain,
  • high blood pressure (hypertension),
  • fever,
  • fluid retention (edema),
  • diarrhea,
  • dry mouth,
  • cough,
  • pneumonia,
  • decreased lymphocytes,
  • decreased neutrophils,
  • decreased phosphate,
  • decreased hemoglobin,
  • decreased sodium,
  • decreased calcium, and
  • increased alanine aminotransferase (alt)

QUESTION

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What Is Retevmo?

Retevmo (selpercatinib) is a kinase inhibitor used to treat adult patients with metastatic RET fusion-positive non-small cell lung cancer (NSCLC), adult and pediatric patients 12 years of age and older with advanced or metastatic RET-mutant medullary thyroid cancer (MTC) who require systemic therapy, and adult and pediatric patients 12 years of age and older with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and who are radioactive iodine-refractory (if radioactive iodine is appropriate).

What Is Gavreto?

Gavreto (pralsetinib) is a kinase inhibitor used to treat adult patients with metastatic rearranged during transfection (RET), fusion-positive, non-small cell lung cancer (NSCLC) as detected by an FDA approved test.

What Drugs Interact With Retevmo?

Retevmo may interact with other medicines such as:

  • acid-reducing agents (such as proton pump inhibitors, H2 receptor antagonists, and locally-acting antacids),
  • strong and moderate CYP3A inhibitors or inducers,
  • CYP2C8 and CYP3A substrates, and
  • medications known to prolong the QT interval

What Drugs Interact With Gavreto?

Gavreto may interact with other medicines such as:

  • strong CYP3A inhibitors,
  • combined P-gp and strong CYP3A inhibitors, and
  • strong CYP3A inducers

Tell your doctor all medications and supplements you use.

How Should Retevmo be Taken?

The recommended dosage of Retevmo in adults and pediatric patients 12 years of age or older is based on weight. For weight less than 50 kg: 120 mg orally twice daily; for weight 50 kg or greater: 160 mg orally twice daily.

How Should Gavreto be Taken?

The recommended dosage of Gavreto in adults is 400 mg orally once daily on an empty stomach (no food intake for at least 2 hours before and at least 1 hour after taking Gavreto).

SLIDESHOW

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References
Eli Lilly and Company. Retevmo Product Information

https://www.retevmo.com/

Blueprint Medicines Corporation and Genentech, Inc. Gavreto Product Information

https://gavretohcp.com/

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