Reyvow vs. Ajovy

Reviewed on 10/28/2019

Are Reyvow and Ajovy the Same Thing?

Reyvow (lasmiditan) and Ajovy (fremanezumab-vfrm) Injection are used to prevent or treat migraine.

Reyvow is used for the acute treatment of migraine with or without aura in adults. Reyvow is not indicated for the preventive treatment of migraine.

Ajovy is indicated for the preventive treatment of migraine in adults.

Reyvow and Ajovy belong to different drug classes. Reyvow is a serotonin (5-HT) 1F receptor agonist and Ajovy is a calcitonin gene-related peptide receptor antagonist.

Side effects of Reyvow that are different from Ajovy include dizziness, fatigue, numbness and tingling, sedation, nausea, and vomiting.

Side effects of Ajovy that are different from Reyvow include injection site reactions (pain, swelling, and redness).

Reyvow may interact with alcohol or other CNS depressants, antidepressants, MAO inhibitors, trazodone, dextromethorphan, St. John's wort, medications that lower heart rate, and P-gp or BCRP substrates.

Ajovy may interact with other drugs.

What Are Possible Side Effects of Reyvow?

Common side effects of Reyvow include:

  • dizziness,
  • fatigue,
  • numbness and tingling,
  • sedation,
  • nausea, and
  • vomiting

What Are Possible Side Effects of Ajovy?

Common side effects of Ajovy include:

  • injection site reactions (pain, swelling, and redness)

What Is Reyvow?

Reyvow (lasmiditan) is a serotonin (5-HT) 1F receptor agonist indicated for the acute treatment of migraine with or without aura in adults. Reyvow is not indicated for the preventive treatment of migraine.

What Is Ajovy?

Ajovy (fremanezumab-vfrm) is a calcitonin gene-related peptide antagonist indicated for the preventive treatment of migraine in adults.

QUESTION

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What Drugs Interact With Reyvow?

Reyvow may interact with:

  • alcohol or other CNS depressants,
  • antidepressants,
  • MAO inhibitors,
  • trazodone,
  • dextromethorphan,
  • St. John's wort,
  • medications that lower heart rate, and
  • P-gp or BCRP substrates

What Drugs Interact With Ajovy?

Ajovy may interact with other drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Ajovy; it is unknown how it would affect a fetus. It is unknown if Ajovy passes into breast milk. Consult your doctor before breastfeeding.

How Should Reyvow Be Taken?

The recommended dose of Reyvow is 50 mg, 100 mg, or 200 mg taken orally, as needed. No more than one dose of Reyvow should be taken in 24 hours.

How Should Ajovy Be Taken?

Two subcutaneous dosing options of Ajovy are available to administer the recommended dosage: 225 mg monthly, or 675 mg every 3 months (quarterly). The 675 mg quarterly dosage is administered as three consecutive injections of 225 mg each.

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References
Lilly. Reyvow Drug Information.

https://investor.lilly.com/news-releases/news-release-details/lillys-reyvowtm-lasmiditan-first-and-only-medicine-new-class

Teva Pharmaceuticals. Ajovy Drug Information.

https://www.ajovy.com

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