Reyvow vs. Maxalt

Reviewed on 10/28/2019

Are Reyvow and Maxalt the Same Thing?

Reyvow (lasmiditan) and Maxalt (rizatriptan) are selective serotonin receptor agonists used to treat migraine headaches. Reyvow and Maxalt are not indicated for the preventive treatment of migraine.

Reyvow is a type of migraine medicine called a ditan, while Maxalt is a triptan.

Side effects of Reyvow and Maxalt that are similar include dizziness, sedation/drowsiness, fatigue/tired feeling, feelings of numbness/tingling/numbness/prickling/heat, and nausea.

Side effects of Reyvow that are different from Maxalt include vomiting.

Side effects of Maxalt that are different from Reyvow include mild headache (not a migraine), dry mouth; feeling of pain or tightness in the jaw, neck, or throat; pressure or heavy feeling in any part of your body, weakness, and flushing (warmth, redness, or tingling feeling under your skin).

Both Reyvow and Maxalt may interact with antidepressants.

Reyvow may also interact with alcohol or other CNS depressants, MAO inhibitors, trazodone, dextromethorphan, St. John's wort, medications that lower heart rate, and P-gp or BCRP substrates.

Maxalt may also interact with other migraine headache medicines and propranolol.

What Are Possible Side Effects of Reyvow?

Common side effects of Reyvow include:

  • dizziness,
  • fatigue,
  • numbness and tingling,
  • sedation,
  • nausea, and
  • vomiting

What Are Possible Side Effects of Maxalt?

Common side effects of Maxalt include:

  • mild headache (not a migraine),
  • dry mouth,
  • nausea;
  • feeling of pain or tightness in the jaw, neck, or throat;
  • pressure or heavy feeling in any part of your body,
  • dizziness,
  • drowsiness,
  • tired feeling,
  • weakness,
  • feelings of tingling/numbness/prickling/heat, or
  • flushing (warmth, redness, or tingling feeling under your skin).

What Is Reyvow?

Reyvow (lasmiditan) is a serotonin (5-HT) 1F receptor agonist indicated for the acute treatment of migraine with or without aura in adults. Reyvow is not indicated for the preventive treatment of migraine.

What Is Maxalt?

Maxalt (rizatriptan) tablets is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist used to treat the pain of migraine headache. Maxalt is believed to work by narrowing the blood vessels around the brain and by decreasing levels of substances involved in the development of migraine pain. Maxalt will only treat a headache that has already begun. Maxalt will not prevent headaches or reduce the number of attacks.

QUESTION

Who suffers more frequently from migraine headaches? See Answer

What Drugs Interact With Reyvow?

Reyvow may interact with:

  • alcohol or other CNS depressants,
  • antidepressants,
  • MAO inhibitors,
  • trazodone,
  • dextromethorphan,
  • St. John's wort,
  • medications that lower heart rate, and
  • P-gp or BCRP substrates

What Drugs Interact With Maxalt?

Maxalt may interact with other migraine headache medicines, propranolol, or antidepressants. Tell your doctor all medications and supplements you use. It is not known whether this medication is harmful to an unborn baby. Before taking rizatriptan, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is also not known whether rizatriptan passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

How Should Reyvow Be Taken?

The recommended dose of Reyvow is 50 mg, 100 mg, or 200 mg taken orally, as needed. No more than one dose of Reyvow should be taken in 24 hours.

How Should Maxalt Be Taken?

The adult dose of Treximet is 1 mg or 2.5 mg tablets taken with fluid. The dose may be repeated once after 4 hours, for a maximum dose of 5 mg in a 24-hour period.

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References
Lilly. Reyvow Drug Information.

https://investor.lilly.com/news-releases/news-release-details/lillys-reyvowtm-lasmiditan-first-and-only-medicine-new-class

GSK. Maxalt Product Information.

https://www.merck.com/product/usa/pi_circulars/m/maxalt/maxalt_pi.pdf

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