Reyvow vs. Zecuity

Are Reyvow and Zecuity the Same Thing?

Reyvow (lasmiditan) and Zecuity (rizatriptan) are selective serotonin receptor agonists used to treat migraine headaches. Reyvow and Zecuity are not indicated for the preventive treatment of migraine.

Reyvow is a type of migraine medicine called a ditan, while Zecuity is a triptan.

Side effects of Reyvow and Zecuity that are similar include dizziness, sedation/drowsiness, fatigue/tired feeling, feelings of numbness/tingling/numbness/prickling/heat, and nausea.

Side effects of Reyvow that are different from Zecuity include vomiting.

Side effects of Zecuity that are different from Reyvow include mild headache (not a migraine), dry mouth; feeling of pain or tightness in the jaw, neck, or throat; pressure or heavy feeling in any part of your body, weakness, and flushing (warmth, redness, or tingling feeling under your skin).

Both Reyvow and Zecuity may interact with antidepressants.

Reyvow may also interact with alcohol or other CNS depressants, MAO inhibitors, trazodone, dextromethorphan, St. John's wort, medications that lower heart rate, and P-gp or BCRP substrates.

Zecuity may also interact with other migraine headache medicines and propranolol.

What Are Possible Side Effects of Reyvow?

Common side effects of Reyvow include:

  • dizziness,
  • fatigue,
  • numbness and tingling,
  • sedation,
  • nausea, and
  • vomiting

What Are Possible Side Effects of Zecuity?

Common side effects of Zecuity include:

  • application site skin reactions including pain,
  • itching,
  • tingling or numbness,
  • discomfort,
  • warmth,
  • discoloration,
  • irritation,
  • bruising,
  • dermatitis (rash),
  • skin lesions,
  • changes in skin color, or
  • cysts.

What Is Reyvow?

Reyvow (lasmiditan) is a serotonin (5-HT) 1F receptor agonist indicated for the acute treatment of migraine with or without aura in adults. Reyvow is not indicated for the preventive treatment of migraine.

What Is Zecuity?

Zecuity (sumatriptan) is a transdermal system (patch) selective serotonin receptor agonist used to treat acute migraine with or without aura in adults.

What Drugs Interact With Reyvow?

Reyvow may interact with:

  • alcohol or other CNS depressants,
  • antidepressants,
  • MAO inhibitors,
  • trazodone,
  • dextromethorphan,
  • St. John's wort,
  • medications that lower heart rate, and
  • P-gp or BCRP substrates

What Drugs Interact With Zecuity?

Zecuity may interact with selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs) such as:

These medications can cause a potentially life-threatening condition called serotonin syndrome.

Zecuity may also interact with:

  • ergot drugs,
  • monoamine oxidase inhibitors (MAOIs), and
  • other 5-HT1 drugs such as triptans

Tell your doctor all medications and supplements you use.

How Should Reyvow Be Taken?

The recommended dose of Reyvow is 50 mg, 100 mg, or 200 mg taken orally, as needed. No more than one dose of Reyvow should be taken in 24 hours.

How Should Zecuity Be Taken?

Zecuity delivers 6.5 mg of sumatriptan in a transdermal system (patch) over a period of 4 hours. No more than two Zecuity patches should be used in any 24-hour period. A second Zecuity patch should be used no sooner than 2 hours after activation of first.


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Lilly. Reyvow Drug Information.

Teva Pharmaceuticals. Zecuity Product Information.

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