Last reviewed on RxList: 4/14/2021
Rhogam Side Effects Center

What Is Rhogam?

RhoGAM (rhod immune globulin human) is a sterilized solution made from human blood used to prevent an immune response to Rh positive blood in people with an Rh negative blood type. RhoGAM may also be used in the treatment of immune thrombocytopenic purpura (ITP). Rh is a substance that most people have in their blood (Rh positive) but some people don't (Rh negative). An Rh negative person can be exposed to Rh positive blood through a mismatched blood transfusion or during pregnancy when the baby has the opposite blood type. RhoGAM is available in generic form.

What Are Side Effects of Rhogam?

Common side effects of RhoGAM include:

  • injection site reactions (pain discomfort, or tenderness),
  • fever,
  • joint or muscle pain,
  • headache,
  • dizziness,
  • weakness,
  • tiredness,
  • itching,
  • skin rash,
  • nausea,
  • diarrhea,
  • vomiting,
  • stomach pain,
  • or an allergic reaction to tiny amounts of proteins in the injection.

Tell your doctor if you have a serious side effect of RhoGAM including:

  • chills,
  • shaking,
  • back pain,
  • dark colored urine,
  • rapid breathing,
  • shortness of breath,
  • urinating less than usual or not at all,
  • swelling,
  • rapid weight gain,
  • pale skin,
  • easy bruising or bleeding,
  • rapid heart rate,
  • trouble concentrating, or
  • feeling light-headed.

Dosage for Rhogam

A single 300 mcg dose RhoGAM is usual for the indications associated with pregnancy.

What Drugs, Substances, or Supplements Interact with Rhogam?

There may be other drugs that can interact with RhoGAM. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Rhogam During Pregnancy or Breastfeeding

RhoGAM is used during and after pregnancy. This medication is not known to be harmful to a baby during pregnancy or while breastfeeding.

Additional Information

Our RhoGAM (rhod immune globulin human) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


The first sign of pregnancy is most often: See Answer
Rhogam Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: rash or hives; feeling light-headed, chest tightness, difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fever, chills, shaking, back pain, unusual weakness, red or pink urine;
  • pale or yellowed skin, dark colored urine;
  • rapid breathing, rapid heart rate, confusion, feeling short of breath;
  • signs of kidney failure--little or no urinating, swelling, rapid weight gain; or
  • signs of a blood clot--sudden numbness or weakness, slurred speech, problems with vision or balance, chest pain, coughing up blood, swelling with redness and warmth in one or both legs.

Common side effects may include:

  • nausea, diarrhea, vomiting, stomach pain;
  • headache, dizziness;
  • drowsiness, weakness, general ill feeling;
  • joint or muscle pain;
  • flushing (warmth, redness, or tingly feeling);
  • mild itching or skin rash;
  • increased sweating; or
  • pain or tenderness where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Rhogam (Rho(D) Immune Globulin (Human))


13 Early Signs & Symptoms of Pregnancy See Slideshow
Rhogam Professional Information


Adverse events (AE) after administration of RhoGAM (rho(d) immune globulin (human)) Ultra-Filtered and MICRhoGAM (rho(d) immune globulin (human)) Ultra-Filtered are reported infrequently.

The most frequently reported AEs are anti-D formation and skin reactions, such as swelling, induration, redness and mild pain at the site of injection. Systemic allergic reactions to RhoGAM (rho(d) immune globulin (human)) or MICRhoGAM (rho(d) immune globulin (human)) are extremely rare. There have been no reported fatalities due to anaphylaxis or any other cause related to RhoGAM (rho(d) immune globulin (human)) or MICRhoGAM (rho(d) immune globulin (human)) administration.

As with any Rho(D) Immune Globulin (Human), administration to patients who have received Rh-positive red blood cells may result in signs and symptoms of a hemolytic reaction, including fever, back pain, nausea and vomiting, hypo- or hypertension, hemoglobinuria/emia, elevated bilirubin and creatinine and decreased haptoglobin.

Read the entire FDA prescribing information for Rhogam (Rho(D) Immune Globulin (Human))

© Rhogam Patient Information is supplied by Cerner Multum, Inc. and Rhogam Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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