Medical Editor: John P. Cunha, DO, FACOEP
Ridaura (auranofin) is a gold preparation used in the management of adults with active (classical or definite) rheumatoid arthritis who have not responded to adequate trials of conventional anti-inflammatory therapy. Ridaura might also be of benefit in patients with psoriatic arthritis. Common side effects of Ridaura include diarrhea, rash, itching, abdominal pain, and inflammation or sores in the mouth.
The usual adult starting dosage of Ridaura is 6 mg per day. Ridaura may interact with phenytoin. Tell your doctor all medications and supplements you use. Ridaura is not recommended for use during pregnancy. Women are advised to avoid pregnancy during treatment with Ridaura and for at least six months after because of the slow excretion of gold and its persistence in the body tissues after discontinuation of treatment. It is unknown if Ridaura passes into breast milk. However, injectable gold passes into breast milk. Ridaura is not recommended for use while breastfeeding.
Our Ridaura (auranofin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
The adverse reactions incidences listed below are based on observations of 1) 4,784 RIDAURA treated patients in clinical trials (2,474 U.S., 2,310 foreign), of whom 2,729 were treated more than one year and 573 for more than three years; and 2) postmarketing experience. The highest incidence is during the first six months of treatment; however, reactions can occur after many months of therapy. With rare exceptions, all patients were on concomitant nonsteroidal anti-inflammatory therapy; some of them were also taking low dosages of corticosteroids.
Reactions occurring in more than 1% of RIDAURA-treated patients
Hepatic: elevated liver enzymes.
*Reactions marked with an asterisk occurred in 3-9% of the patients. The other reactions listed occurred in 1-3%.
Reactions occurring in less than 1% of RIDAURA-treated patients
Mucous Membrane: gingivitis†.
Respiratory: interstitial pneumonitis.
Neurological: peripheral neuropathy.
† Reactions marked with a dagger occurred in 0.1-1% of the patients. The other reactions listed occurred in less than 0.1%.
Reactions reported with injectable gold preparations, but not with RIDAURA (auranofin) (based on clinical trials and on postmarketing experience)
Cutaneous Reactions: generalized exfoliative dermatitis.
Incidence of Adverse Reactions for Specific
Categories— 18 Comparative Trials
|RIDAURA (445 patients)||Injectable Gold (445 patients)|
|Elevated liver function tests||1.9%||1.7%|
Read the entire FDA prescribing information for Ridaura (auranofin)