Rinvoq vs. Simponi

Are Simponi and Rinvoq the Same Thing?

Rinvoq (upadacitinib) and Simponi (golimumab injection) are used to treat rheumatoid arthritis.

Simponi is also used to treat psoriatic arthritis and ankylosing spondylitis. Simponi is sometimes used with another medication called methotrexate (Rheumatrex, Trexall).

Rinvoq and Simponi belong to different drug classes. Rinvoq is a Janus kinase (JAK) inhibitor and Simponi is a tumor necrosis factor (TNF) blocker.

Side effects of Rinvoq that are different from Simponi include upper respiratory tract infections, nausea, cough, and fever.

Side effects of Simponi that are different from Rinvoq include dizziness, cold symptoms (stuffy nose, sneezing, sore throat), and injection site reactions (redness, itching, pain, or swelling).

Both Rinvoq and Simponi may interact with live vaccines.

Rinvoq may also interact with strong CYP3A4 inhibitors (e.g., ketoconazole) and strong CYP3A4 inducers (e.g., rifampin).

Simponi may also interact with abatacept, anakinra, rituximab, blood thinners, cyclosporine, digoxin, theophylline, seizure medications, and heart rhythm medications.

What Are Possible Side Effects of Rinvoq?

Common side effects of Rinvoq include:

  • upper respiratory tract infections,
  • nausea,
  • cough, and
  • fever

What Are Possible Side Effects of Simponi?

Side effects of Simponi nclude<:/p>

  • dizziness,
  • cold symptoms (stuffy nose, sneezing, sore throat), or
  • injection site reactions (redness, itching, pain, or swelling).

Tell your doctor if you have serious side effects of Simponi including:

What Is Rinvoq?

Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor indicated for the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate.

What Is Simponi?

Simponi (golimumab injection) is a human IgG1k monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Simponi is sometimes used with another medication called methotrexate (Rheumatrex, Trexall). Simponi works by blocking a protein (tumor necrosis factor or TNF) found in the body's immune system that causes joint swelling and damage.

SLIDESHOW

What Is Rheumatoid Arthritis (RA)? Symptoms, Treatment, Diagnosis See Slideshow

What Drugs Interact With Rinvoq?

Rinvoq may interact with strong CYP3A4 inhibitors (e.g., ketoconazole), strong CYP3A4 inducers (e.g., rifampin), and live vaccines. Tell your doctor all medications and supplements you use. Rinvoq is not recommended for use during pregnancy; it may harm a fetus. Females of reproductive potential are advised to use effective contraception during treatment with Rinvoq and for 4 weeks following completion of therapy. It is unknown if Rinvoq passes into breast milk. Because of the potential for serious adverse reactions in the breastfed infant, breastfeeding is not recommended during treatment with Rinvoq, and for 6 days after the last dose.

What Drugs Interact With Simponi?

Simponi may interact with abatacept, anakinra, rituximab, blood thinners, cyclosporine, digoxin, theophylline, seizure medications, or heart rhythm medications. Tell your doctor all medications you use. During pregnancy, Simponi should be used only when prescribed. It is unknown if this drug passes into breast milk. Because of the potential risk to the infant, consult your doctor before breastfeeding.

How Should Rinvoq Be Taken?

The recommended dose of Rinvoq is 15 mg once daily. Rinvoq may be used as monotherapy or in combination with methotrexate or other nonbiologic DMARDs.

How Should Simponi Be Taken?

The Simponi dose regimen is 50 mg administered by subcutaneous (SC) injection once a month.

QUESTION

The term arthritis refers to stiffness in the joints. See Answer
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References


FDA. Rinvoq Product Information.

https://www.rinvoq.com

Janssen Biotech, Inc. Simponi Product Information.

https://www.simponi.com/

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