Rituxan vs. Ocrevus

Are Rituxan and Ocrevus the Same Thing?

Rituxan (rituximab) and Ocrevus (ocrelizumab) are monoclonal antibodies used to treat multiple sclerosis (MS).

Rituxan is used off-label to treat MS.

Rituxan is also used in combination with other cancer medicines to treat non-Hodgkin's lymphoma, and in combination with another drug called methotrexate to treat symptoms of adult rheumatoid arthritis.

What Are Possible Side Effects of Rituxan?

Common side effects of Rituxan include:

Tell your doctor if you experience serious side effects of Rituxan including:

  • increased thirst or urination,
  • swelling of the hands or feet, or
  • tingling of the hands or feet.

What Are Possible Side Effects of Ocrevus?

Common side effects of Ocrevus include:

What is Rituxan?

Rituxan (rituximab) is a cancer medication used in combination with other cancer medicines to treat non-Hodgkin's lymphoma. Rituxan is also used in combination with another drug called methotrexate to treat symptoms of adult rheumatoid arthritis.

What is Ocrevus?

Ocrevus (ocrelizumab) injection is aCD20-directed cytolytic antibody indicated for the treatment of patients with relapsing or primary progressive forms of multiple sclerosis.


What kind of disease is multiple sclerosis? See Answer

What Drugs Interact With Rituxan?

Rituxan may interact with cisplatin, adalimumab, auranofin, azathioprine, cyclosporine, etanercept, infliximab, leflunomide, minocycline, sulfasalazine, blood pressure medications, or medication to treat malaria.

What Drugs Interact With Ocrevus?

Ocrevus may interact with other immune-modulating or immunosuppressive therapies, including immunosuppressant doses of corticosteroids. Tell your doctor all medications and supplements you use.

How Should Rituxan Be Taken?

Rituxan is administered under a physician's supervision. The dose of Rituxan varies depending on the disorder being treated and the number of infusions (doses) needed.

How Should Ocrevus Be Taken?

Hepatitis B virus screening is required before the first dose of Ocrevus. Pre-medicate with methylprednisolone (or an equivalent corticosteroid) and an antihistamine prior to each infusion. The starting dose of Ocrevus is 300 mg intravenous infusion, followed two weeks later by a second 300 mg intravenous infusion. Subsequent doses of Ocrevus are 600 mg intravenous infusion every 6 months.


What Is Multiple Sclerosis? MS Symptoms, Causes, Diagnosis See Slideshow

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Genentech. Rituxan Product Monograph.


Genentech. Ocrevus Product Monograph.


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