Rituxan vs. Orencia

Are Rituxan and Orencia the Same Thing?

Rituxan (rituximab) and Orencia (abatacept) are used to treat symptoms of rheumatoid arthritis.

Rituxan is also used in combination with other cancer medicines to treat non-Hodgkin's lymphoma.

Orencia is also used to treat arthritis in children who are at least 6 years old. Orencia is not a cure for any autoimmune disorder and only treats symptoms.

Rituxan is a monoclonal antibody and Orencia is a recombinant DNA generated fusion protein.

Side effects of Rituxan and Orencia that are similar include headache, stomach pain, nausea, diarrhea, heartburn/indigestion, flushing, back pain, and dizziness.

Side effects of Rituxan that are different from Orencia include fever, chills, night sweats, weakness, and muscle or joint pain.

Side effects of Orencia that are different from Rituxan include cold symptoms such as stuffy head/nose, sneezing, sore throat, or cough.

Both Rituxan and Orencia may interact with monoclonal antibodies and etanercept.

Rituxan may also interact with cisplatin, auranofin, azathioprine, cyclosporine, leflunomide, minocycline, sulfasalazine, blood pressure medications, or medications to treat malaria.

Orencia may also interact with anakinra and "live" vaccines.

What Are Possible Side Effects of Rituxan?

Common side effects of Rituxan include:

  • headache,
  • fever,
  • chills,
  • stomach pain,
  • nausea,
  • diarrhea,
  • heartburn,
  • flushing,
  • night sweats,
  • weakness,
  • muscle or joint pain,
  • back pain, or
  • dizziness.

Tell your doctor if you experience serious side effects of Rituxan including:

  • increased thirst or urination,
  • swelling of the hands or feet, or
  • tingling of the hands or feet.

What Are Possible Side Effects of Orencia?

Common side effects of Orencia include:

  • headache,
  • nausea,
  • diarrhea,
  • stomach pain,
  • indigestion,
  • dizziness,
  • flushing,
  • back pain, or
  • cold symptoms such as stuffy head/nose, sneezing, sore throat, or cough.

Serious side effects of Orencia include:

What Is Rituxan?

Rituxan (rituximab) is a cancer medication used in combination with other cancer medicines to treat non-Hodgkin's lymphoma. Rituxan is also used in combination with another drug called methotrexate to treat symptoms of adult rheumatoid arthritis.

What Is Orencia?

Orencia (abatacept) is a recombinant DNA generated fusion protein used to treat the symptoms of rheumatoid arthritis and to prevent joint damage caused by these conditions. Orencia is also used to treat arthritis in children who are at least 6 years old. Orencia is not a cure for any autoimmune disorder and only treats symptoms.

QUESTION

The term arthritis refers to stiffness in the joints. See Answer

What Drugs Interact With Rituxan?

Rituxan may interact with cisplatin, adalimumab, auranofin, azathioprine, cyclosporine, etanercept, infliximab, leflunomide, minocycline, sulfasalazine, blood pressure medications, or medication to treat malaria.

What Drugs Interact With Orencia?

There may be other drugs that can interact with Orencia. The prescribing doctor needs to know all medications (including herbals) that the person is taking. During pregnancy, Orencia should be used only when prescribed. It is unknown if Orencia passes into breast milk or if it would harm a nursing baby. Breastfeeding is not recommended while using this drug.

How Should Rituxan Be Taken?

Rituxan is administered under a physician's supervision. The dose of Rituxan varies depending on the disorder being treated and the number of infusions (doses) needed.

How Should Orencia Be Taken?

Orencia is supplied in single use vials at a strength of 250mg per vial. Orencia is administered intravenously (IV) as a 30-minute infusion. Dosing is based on the patient's weight. Following the initial intravenous administration, an IV infusion is given at 2 and 4 weeks after the first infusion and every 4 weeks thereafter.

SLIDESHOW

What Is Rheumatoid Arthritis (RA)? Symptoms, Treatment, Diagnosis See Slideshow
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References
SOURCE:

Genentech. Rituxan Product Information.

https://www.genentech-access.com/hcp/brands/rituxan/rituxan-ra.html


Bristol-Myers Squibb Company. Orencia Product Information.

http://www.orenciahcp.com

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