Rituxan vs. Rituxan Hycela

Are Rituxan and Rituxan Hycela the Same Thing?

Rituxan (rituximab) and Rituxan Hycela (rituximab and hyaluronidase human) are monoclonal antibodies used to treat different types of lymphomas.

Rituxan is also used in combination with another drug called methotrexate to treat symptoms of adult rheumatoid arthritis.

Rituxan Hycela is a combination of a monoclonal antibody and an endoglycosidase also used to treat chronic lymphocytic leukemia (CLL).

What Are Possible Side Effects of Rituxan?

Common side effects of Rituxan include:

Tell your doctor if you experience serious side effects of Rituxan including:

  • increased thirst or urination,
  • swelling of the hands or feet, or
  • tingling of the hands or feet.

What Are Possible Side Effects of Rituxan Hycela?

Common side effects of Rituxan Hycela include:

What is Rituxan?

Rituxan (rituximab) is a cancer medication used in combination with other cancer medicines to treat non-Hodgkin's lymphoma. Rituxan is also used in combination with another drug called methotrexate to treat symptoms of adult rheumatoid arthritis.

What is Rituxan Hycela?

Rituxan Hycela (rituximab and hyaluronidase human) injection is a combination of a CD20-directed cytolytic antibody and an endoglycosidase, indicated for the treatment of adult patients with: Follicular Lymphoma (FL), Diffuse Large B-cell Lymphoma (DLBCL), and Chronic Lymphocytic Leukemia (CLL).


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What Drugs Interact With Rituxan?

Rituxan may interact with cisplatin, adalimumab, auranofin, azathioprine, cyclosporine, etanercept, infliximab, leflunomide, minocycline, sulfasalazine, blood pressure medications, or medication to treat malaria.

What Drugs Interact With Rituxan Hycela?

Rituxan Hycela may interact with other drugs and certain vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received.

How Should Rituxan Be Taken?

Rituxan is administered under a physician's supervision. The dose of Rituxan varies depending on the disorder being treated and the number of infusions (doses) needed.

How Should Rituxan Hycela Be Taken?

The dose of Rituxan Hycela depends on the condition being treated. All patients must receive at least one full dose of a rituximab product by intravenous infusion before receiving Rituxan Hycela by subcutaneous injection.


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Genentech. Rituxan Product Monograph.


Genentech. Rituxan Hycela Product Monograph.


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