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Robinul vs. Ditropan

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Are Robinul and Ditropan the Same Thing?

Robinul Injection (glycopyrrolate) and Ditropan (oxybutynin chloride) are anticholinergics used to treat different conditions.

Robinul Injection helps to control conditions such as peptic ulcers that involve excessive stomach acid production. The injectable form of Robinul is also used to reduce saliva, nasal, lung, and stomach secretions and to help control heart rate during surgery.

Ditropan is an antispasmodic used to treat symptoms of overactive bladder, such as frequent or urgent urination, incontinence (urine leakage), and increased night-time urination.

Side effects of Robinul and Ditropan that are similar include drowsiness, dizziness, weakness, blurred vision, dry eyes, dry mouth, vomiting, or constipation.

Side effects of Robinul that are different from Ditropan include abdominal bloating, stuffy nose, sinus pain, or flushing (warmth, redness, or tingly feeling).

Side effects of Ditropan that are different from Robinul include nausea, upset stomach, stomach pain, diarrhea, headache, unusual taste in mouth, dry/flushed skin, sleep problems, or runny nose.

Both Robinul and Ditropan may interact with antidepressants.

Robinul may also interact with alcohol, amantadine, quinidine, antihistamines, decongestants, appetite suppressants, or phenothiazines.

Ditropan may also interact with other bladder or urinary medications, glycopyrrolate, flecainide, mepenzolate, thioridazine, HIV /AIDS medicine, antibiotics, antifungal medications, atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bronchodilators, or irritable bowel medications.

What Are Possible Side Effects of Robinul?

Common side effects of Robinul include:

  • drowsiness,
  • dizziness,
  • weakness,
  • blurred vision,
  • dry eyes,
  • dry mouth,
  • vomiting,
  • constipation,
  • abdominal bloating,
  • stuffy nose,
  • sinus pain, or
  • flushing (warmth, redness, or tingly feeling).

Tell your doctor if you experience unlikely but serious side effects of Robinul Injection including:

  • decreased sweating,
  • fast/irregular heartbeat,
  • mental/mood changes (such as confusion, hallucinations, agitation, nervousness, unusual excitement),
  • difficulty urinating, or
  • decreased sexual ability.

What Are Possible Side Effects of Ditropan?

Common side effects of Ditropan include:

  • dry mouth,
  • dizziness,
  • drowsiness,
  • blurred vision,
  • dry eyes,
  • nausea,
  • vomiting,
  • upset stomach,
  • stomach pain,
  • constipation,
  • diarrhea,
  • headache,
  • unusual taste in mouth,
  • dry/flushed skin,
  • weakness,
  • sleep problems, or
  • runny nose.

Tell your doctor if you experience serious side effects of Ditropan including:

  • decreased sexual activity,
  • difficulty urinating,
  • fast or pounding heartbeat,
  • signs of kidney infection (such as burning/painful/frequent urination, lower back pain, fever),
  • mental/mood changes (such as confusion),
  • swelling of arms/legs/ankles/feet,
  • vision problems (including eye pain),
  • seizures, or
  • stomach or intestinal blockage (such as persistent nausea or vomiting, or prolonged constipation).

What Is Robinul?

Robinul Injection (glycopyrrolate) is an anticholinergic that helps to control conditions such as peptic ulcers that involve excessive stomach acid production. The injectable form of Robinul is also used to reduce saliva, nasal, lung, and stomach secretions and to help control heart rate during surgery. Robinul Injection is available in generic form.

What Is Ditropan?

Ditropan (oxybutynin chloride) is an antispasmodic and anticholinergic used to treat symptoms of overactive bladder, such as frequent or urgent urination, incontinence (urine leakage), and increased night-time urination. Ditropan is available in generic form.

What Drugs Interact With Robinul?

Robinul may interact with amantadine, quinidine, antihistamines, decongestants, appetite suppressants, phenothiazines, or antidepressants. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy, Robinul should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Ditropan?

Some products that may adversely interact with Ditropan include other bladder or urinary medications, glycopyrrolate, flecainide, mepenzolate, thioridazine, HIV /AIDS medicine, antibiotics, antifungal medications, atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bronchodilators, irritable bowel medications, or antidepressants. Tell your doctor all medications you are taking. Ditropan should be used only when prescribed by your doctor during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breastfeeding.

How Should Robinul Be Taken?

Robinul injection is administered intramuscularly (IM) or intravenously (IV), under a physician's supervision. Dose depends on the condition being treated.

How Should Ditropan Be Taken?

The usual adult dose of Ditropan is one 5-mg tablet 2-3 times a day. The maximum recommended adult dose is one 5-mg tablet four times a day. The usual pediatric dose is one 5-mg tablet two times a day. The maximum recommended pediatric dose is one 5-mg tablet three times a day. Doses may be adjusted by your doctor.

Reviewed on 4/15/2019

SOURCE:

Mylan. Glycopyrrolate (Robinul) Product Information.

https://www.mylan.com/en/products/product-catalog/product-profile-page?id=402197af-c04e-455a-9eed-c1249f187dc7

Janssen. Ditropan Product Information.

https://www.janssen.com/canada/sites/www_janssen_com_canada/files/prod_files/live/ditropan_cpm.pdf

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